重症过敏性紫癜性肾炎：硫唑嘌呤与类固醇治疗后缓解

Severe Henoch-Schönlein nephritis: resolution with azathioprine and steroids.

作者信息

Singh Surjit, Kumar Lata, Joshi Kusum, Minz Ranjana W, Datta Usha

机构信息

Department of Pediatrics, Advanced Pediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

出版信息

Rheumatol Int. 2002 Aug;22(4):133-7. doi: 10.1007/s00296-002-0208-9. Epub 2002 Jul 5.

DOI:10.1007/s00296-002-0208-9

PMID:12172950

Abstract

AIM

The aim of this study was to assess the efficacy of long-term azathioprine and steroids for treatment of severe nephritis in children with Henoch-Schönlein purpura (HSP).

METHODS

Analysis of case records of children with HSP followed up for a mean duration of 4.7 years (range 6 months-6.5 years) was performed. All underwent clinical status evaluation followed by percutaneous kidney biopsies. Renal histological changes were graded according to the International Study of Kidney Disease in Childhood (ISKDC) classification. Nine children with severe nephritis (grades III and IV) received steroids (mean duration 12.1 months) and long-term azathioprine (mean duration 14.7 months), while two children received steroids alone.

RESULTS

All nine children in the former category showed sustained clinical and biochemical remission, while the two children in the latter category did not.

CONCLUSION

Severe nephritis seen in association with HSP can be effectively treated with a combination of azathioprine and steroids.

摘要

目的

本研究旨在评估长期使用硫唑嘌呤和类固醇治疗儿童过敏性紫癜（HSP）重症肾炎的疗效。

方法

对平均随访4.7年（范围6个月至6.5年）的HSP患儿病例记录进行分析。所有患儿均接受临床状况评估，随后进行经皮肾活检。肾脏组织学变化根据儿童肾脏病国际研究（ISKDC）分类进行分级。9例重症肾炎（III级和IV级）患儿接受了类固醇治疗（平均疗程12.1个月）和长期硫唑嘌呤治疗（平均疗程14.7个月），而2例患儿仅接受了类固醇治疗。