Brzonova I, Wollenberg A, Prinz J C
Department of Dermatology and Venereology, Charles University, 2nd Medical School, Motol University Hospital, V Uvalu 84, 15006 Prague, Czech Republic.
Br J Dermatol. 2002 Aug;147(2):375-8. doi: 10.1046/j.1365-2133.2002.04792.x.
Borrelia burgdorferi is a major cause of morbidity in wooded area in western Europe and the eastern seaboard of the U.S.A. Diagnosis of late stage infection and associated disorders may be difficult and often requires an array of different diagnostic procedures. Here we report an 11-year-old girl with acrodermatitis chronica atrophicans affecting all four limbs and parts of the trunk. The diagnosis was made on the basis of clinical appearance, serological and histopathological findings, and the lesional detection of B. burgdorferi-specific gene segments by polymerase chain reaction. This very unusual, severe case illustrates that despite being a late manifestation of tick-borne B.burgdorferi infection, usually occurring in adults, acrodermatitis chronica atrophicans may already appear at a young age and may be characterized by extensive skin involvement.
伯氏疏螺旋体是西欧林区和美国东海岸发病的主要原因。晚期感染及相关病症的诊断可能困难，通常需要一系列不同的诊断程序。在此，我们报告一名11岁女孩，患有慢性萎缩性肢端皮炎，累及四肢及躯干部分。诊断依据临床表现、血清学和组织病理学检查结果，以及通过聚合酶链反应在病变部位检测到伯氏疏螺旋体特异性基因片段。这个非常罕见的严重病例表明，尽管慢性萎缩性肢端皮炎通常是蜱传播的伯氏疏螺旋体感染的晚期表现，多见于成人，但也可能在幼年时就出现，且可能以广泛的皮肤受累为特征。
