Hammers-Berggren S, Lebech A M, Karlsson M, Andersson U, Hansen K, Stiernstedt G
Department of Infectious Diseases, Karolinska Institute, Danderyd Hospital, Sweden.
Scand J Infect Dis. 1994;26(3):339-47. doi: 10.3109/00365549409011804.
To study the serological response to Borrelia burgdorferi after treatment of late Lyme borreliosis, consecutive serum samples from 20 patients with Borrelia arthritis and 21 with acrodermatitis chronica atrophicans were analysed with capture IgM ELISA and indirect IgG ELISA, both using B. burgdorferi flagella as antigen. Seven patients had positive IgM OD values, whereas all 41 had positive IgG OD values before therapy. In the majority, highly elevated IgG OD values were seen. All patients improved after antibiotic therapy, 32 recovering completely, while 9 had sequelae. At follow-up after 6 months to 5 years, 4/7 patients became negative IgM ELISA, whereas 3 still had slightly elevated IgM OD values 6 months, 1 year and 4.5 years, respectively, after therapy. Only one patient became negative in IgG ELISA during follow-up, although a significant decline in IgG OD values was seen in 22 of the remaining 40 initially IgG-positive patients. The serological response after successful treatment of Borrelia arthritis and acrodermatitis chronica atrophicans may persist for several years even with highly elevated IgG OD values in patients who have recovered completely.
为研究晚期莱姆病治疗后对伯氏疏螺旋体的血清学反应，采用捕获IgM ELISA和间接IgG ELISA对20例伯氏疏螺旋体关节炎患者和21例慢性萎缩性肢端皮炎患者的连续血清样本进行分析，两种方法均以伯氏疏螺旋体鞭毛作为抗原。7例患者IgM OD值为阳性，而所有41例患者在治疗前IgG OD值均为阳性。大多数患者的IgG OD值显著升高。所有患者经抗生素治疗后均有改善，32例完全康复，9例有后遗症。在6个月至5年的随访中，7例IgM ELISA阳性患者中有4例转阴，而3例在治疗后6个月、1年和4.5年时IgM OD值仍略有升高。随访期间，只有1例患者IgG ELISA转阴，尽管其余40例最初IgG阳性患者中有22例IgG OD值显著下降。即使完全康复的患者IgG OD值显著升高，成功治疗伯氏疏螺旋体关节炎和慢性萎缩性肢端皮炎后的血清学反应仍可能持续数年。
