Jin Hongkui, Yang Renhui, Lu Hsienwie, Ogasawara Annie K, Li Wei, Ryan Anne, Peale Franklin, Paoni Nicholas F
Department of Cardiovascular Research, Genentech, Inc., South San Francisco, CA 94080, USA.
Growth Horm IGF Res. 2002 Aug;12(4):208-15. doi: 10.1016/s1096-6374(02)00042-4.
This study examined the effects of growth hormone (GH) on infarct size, survival, and cardiac gene expression in rats with acute myocardial infarction.
Animals randomly received sc injection of either saline vehicle (n = 98) or GH (2mg/kg/day, n = 105) for 14 days commencing the day of left coronary artery ligation. Infarct size was determined by morphometric analysis at the time of death or at 52 weeks post-surgery. Gene expression was analyzed by real-time RT-PCR after 2-week treatment.
GH decreased infarct size by 18% (P < 0.01) and increased survival by 36% at 52 weeks. GH also significantly reduced cardiac expression of atrial natriuretic factor, beta-myosin heavy chain, alpha-smooth muscle actin, collagen I, collagen III, fibronectin, and pro-inflammatory cytokines.
Treatment with GH for 2 weeks beginning on the day of myocardial infarction produced beneficial effects that were associated with reductions in cardiac gene expression symptomatic of pathological remodeling.
本研究探讨了生长激素（GH）对急性心肌梗死大鼠梗死面积、生存率及心脏基因表达的影响。
动物在左冠状动脉结扎当天开始，随机皮下注射生理盐水（n = 98）或生长激素（2mg/kg/天，n = 105），持续14天。在死亡时或术后52周通过形态学分析确定梗死面积。治疗2周后通过实时逆转录聚合酶链反应分析基因表达。
生长激素使梗死面积减少18%（P < 0.01），并使52周时的生存率提高36%。生长激素还显著降低了心钠素、β-肌球蛋白重链、α-平滑肌肌动蛋白、I型胶原、III型胶原、纤连蛋白和促炎细胞因子的心脏表达。
心肌梗死当天开始用生长激素治疗2周产生了有益效果，这与心脏基因表达降低有关，而这些基因表达是病理重塑的症状表现。
