生长激素与心血管系统：这一心脏领域的热门话题最新进展
GH and the cardiovascular system: an update on a topic at heart.
机构信息
Laboratory of Experimental Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 8, 413 45, Göteborg, Sweden,
出版信息
Endocrine. 2015 Feb;48(1):25-35. doi: 10.1007/s12020-014-0327-6. Epub 2014 Jun 28.
Abstract
In this review, the importance of growth hormone (GH) for the maintenance of normal cardiac function in adult life is discussed. Physiological effects of GH and underlying mechanisms for interactions between GH and insulin-like growth factor I (IGF-I) and the cardiovascular system are covered as well as the cardiac dysfunction caused both by GH excess (acromegaly) and by GH deficiency in adult hypopituitary patients. In both acromegaly and adult GH deficiency, there is also increased cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Finally, the status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed in this article.
摘要
在这篇综述中，讨论了生长激素 (GH) 对维持成年人心血管功能正常的重要性。涵盖了 GH 的生理作用以及 GH 与胰岛素样生长因子 I (IGF-I) 和心血管系统相互作用的潜在机制，以及 GH 过多（肢端肥大症）和成年垂体功能减退患者 GH 缺乏引起的心脏功能障碍。在肢端肥大症和成年 GH 缺乏症中，心血管发病率和死亡率也增加，这可能与 GH 状态的异常有关。最后，本文还回顾了 GH/IGF-I 系统与心力衰竭的关系以及 GH 作为心力衰竭治疗的一种治疗工具的潜力。
相似文献
1
GH and the cardiovascular system: an update on a topic at heart.生长激素与心血管系统：这一心脏领域的热门话题最新进展
Endocrine. 2015 Feb;48(1):25-35. doi: 10.1007/s12020-014-0327-6. Epub 2014 Jun 28.
2
Role of growth hormone in chronic heart failure: therapeutic implications.生长激素在慢性心力衰竭中的作用：治疗意义。
Ital Heart J. 2000 Nov;1(11):732-8.
3
Growth hormone and the cardiovascular function.生长激素与心血管功能。
Minerva Endocrinol. 2005 Mar;30(1):1-13.
4
The GH-IGF-I axis and the cardiovascular system: clinical implications.生长激素-胰岛素样生长因子-I轴与心血管系统：临床意义。
Clin Endocrinol (Oxf). 2008 Sep;69(3):347-58. doi: 10.1111/j.1365-2265.2008.03292.x. Epub 2008 May 6.
5
Pharmacologic therapy in growth hormone disorders and the heart.生长激素紊乱与心脏的药物治疗
Curr Med Chem. 2007;14(13):1399-407. doi: 10.2174/092986707780831195.
6
Growth hormone and the cardiovascular system.生长激素与心血管系统。
Cardiol Rev. 2012 Jul-Aug;20(4):197-207. doi: 10.1097/CRD.0b013e318248a3e1.
7
Role of growth hormone in chronic heart failure. Therapeutic implications.生长激素在慢性心力衰竭中的作用。治疗意义。
Drugs. 2000 Oct;60(4):711-9. doi: 10.2165/00003495-200060040-00002.
8
Cardiological aspects of growth hormone and insulin-like growth factor-I.生长激素和胰岛素样生长因子-I的心脏学方面
J Pediatr Endocrinol Metab. 1997 Nov-Dec;10(6):553-60. doi: 10.1515/jpem.1997.10.6.553.
9
The GH/IGF-1 axis in chronic heart failure.慢性心力衰竭中的生长激素/胰岛素样生长因子-1轴
Endocr Metab Immune Disord Drug Targets. 2013 Mar;13(1):76-91. doi: 10.2174/1871530311313010010.
10
Growth hormone and cardiac function.生长激素与心脏功能。
Ann Endocrinol (Paris). 2000 Feb;61(1):16-21.
引用本文的文献
1
Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly-A Preliminary Study.copeptin和中段前肾上腺髓质素并非肢端肥大症患者心脏代谢疾病的有用生物标志物——一项初步研究
Biomedicines. 2025 Mar 8;13(3):666. doi: 10.3390/biomedicines13030666.
2
Long-Acting Growth Hormone for Pediatric Growth Hormone Deficiency.用于儿童生长激素缺乏症的长效生长激素
J Endocr Soc. 2025 Mar 4;9(5):bvaf040. doi: 10.1210/jendso/bvaf040. eCollection 2025 May.
3
Diastolic Dysfunction with Normal Ejection Fraction and Reduced Heart Rate in Mice Expressing Human Growth Hormone and Displaying Signs of Growth Hormone Insufficiency.在表达人生长激素并表现出生长激素不足迹象的小鼠中，射血分数正常但心率降低的舒张功能障碍。
Int J Mol Sci. 2024 Dec 31;26(1):269. doi: 10.3390/ijms26010269.
4
GH Therapy in Chronic Heart Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.生长激素疗法治疗慢性心力衰竭：随机对照试验的系统评价与荟萃分析
J Clin Endocrinol Metab. 2025 Mar 17;110(4):e1252-e1260. doi: 10.1210/clinem/dgae814.
5
Growth hormone-releasing hormone and its analogues in health and disease.生长激素释放激素及其类似物在健康与疾病中的作用
Nat Rev Endocrinol. 2025 Mar;21(3):180-195. doi: 10.1038/s41574-024-01052-1. Epub 2024 Nov 13.
6
Electrocardiographic ventricular arrhythmia parameters during diagnosis and after the treatment of acromegaly: A case-control study.肢端肥大症诊断期间及治疗后的心电图室性心律失常参数：一项病例对照研究。
Heliyon. 2024 Sep 19;10(19):e38033. doi: 10.1016/j.heliyon.2024.e38033. eCollection 2024 Oct 15.
7
Serum insulin-like growth factor-1 as a potential prognostic biomarker for heart failure with reduced ejection fraction: a meta-analysis.血清胰岛素样生长因子-1作为射血分数降低的心力衰竭潜在预后生物标志物的荟萃分析。
Front Cardiovasc Med. 2024 Sep 17;11:1415238. doi: 10.3389/fcvm.2024.1415238. eCollection 2024.
8
The Double-Edged Sword of Total Antioxidant Capacity: Clinical Significance and Personal Experience.总抗氧化能力的双刃剑：临床意义与个人经验
Antioxidants (Basel). 2024 Aug 1;13(8):933. doi: 10.3390/antiox13080933.
9
Cardiovascular Effects of Excess Growth Hormone: How Real is the Threat?生长激素过量的心血管影响：威胁究竟有多大？
Rev Cardiovasc Med. 2023 Mar 23;24(4):95. doi: 10.31083/j.rcm2404095. eCollection 2023 Apr.
10
Influence of growth and metabolic markers on hs-troponin T and NT-proBNP levels in healthy children.生长和代谢标志物对健康儿童高敏肌钙蛋白T和N末端B型利钠肽原水平的影响。
Endocr Connect. 2023 Sep 19;12(10). doi: 10.1530/EC-23-0120. Print 2023 Oct 1.
本文引用的文献
1
Cardiovascular risk in adult patients with growth hormone (GH) deficiency and following substitution with GH--an update.成人生长激素（GH）缺乏症患者的心血管风险及其替代治疗后的情况更新。
J Clin Endocrinol Metab. 2014 Jan;99(1):18-29. doi: 10.1210/jc.2013-2394. Epub 2013 Dec 20.
2
Fifteen years of GH replacement improves body composition and cardiovascular risk factors.15 年的 GH 替代治疗可改善身体成分和心血管危险因素。
Eur J Endocrinol. 2013 Apr 15;168(5):745-53. doi: 10.1530/EJE-12-1083. Print 2013 May.
3
Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients.前瞻性 GH 缺乏症成人安全性监测：治疗与未治疗患者比较。
J Clin Endocrinol Metab. 2013 Mar;98(3):980-8. doi: 10.1210/jc.2012-2684. Epub 2013 Jan 23.
4
Cardiovascular involvement in patients affected by acromegaly: an appraisal.肢端肥大症患者的心血管受累：评估。
Int J Cardiol. 2013 Sep 1;167(5):1712-8. doi: 10.1016/j.ijcard.2012.11.109. Epub 2012 Dec 4.
5
Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status.慢性心力衰竭患者恶病质的流行情况及其身体成分和代谢状态的特征。
Endocrine. 2013 Jun;43(3):626-34. doi: 10.1007/s12020-012-9836-3. Epub 2012 Nov 22.
6
Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly.活性肢端肥大症与 hs-CRP 和 NT-proBNP 血清水平降低相关：来自比利时肢端肥大症登记处的见解。
Eur J Endocrinol. 2013 Jan 17;168(2):177-84. doi: 10.1530/EJE-12-0753. Print 2013 Feb.
7
Cachexia in chronic heart failure: endocrine determinants and treatment perspectives.慢性心力衰竭中的恶病质：内分泌决定因素和治疗观点。
Endocrine. 2013 Apr;43(2):253-65. doi: 10.1007/s12020-012-9767-z. Epub 2012 Aug 19.
8
Testosterone and heart failure.睾酮与心力衰竭。
Endocrine. 2012 Oct;42(2):272-7. doi: 10.1007/s12020-012-9725-9. Epub 2012 Jun 24.
9
Increase in serum pregnancy-associated plasma protein-A is correlated with increase in cardiovascular risk factors in adult patients with growth hormone deficiency.血清妊娠相关血浆蛋白-A 的增加与生长激素缺乏症成年患者心血管危险因素的增加相关。
Endocrine. 2012 Oct;42(2):375-81. doi: 10.1007/s12020-012-9697-9. Epub 2012 May 29.
10
Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin.胰岛素样生长因子轴（胰岛素样生长因子-I/胰岛素样生长因子结合蛋白-3）作为心力衰竭的预后预测因子：与脂联素的关系。
Eur J Heart Fail. 2010 Nov;12(11):1214-22. doi: 10.1093/eurjhf/hfq166. Epub 2010 Sep 17.
Zotero 插件