Laboratory of Experimental Endocrinology, Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 8, 413 45, Göteborg, Sweden,
Endocrine. 2015 Feb;48(1):25-35. doi: 10.1007/s12020-014-0327-6. Epub 2014 Jun 28.
In this review, the importance of growth hormone (GH) for the maintenance of normal cardiac function in adult life is discussed. Physiological effects of GH and underlying mechanisms for interactions between GH and insulin-like growth factor I (IGF-I) and the cardiovascular system are covered as well as the cardiac dysfunction caused both by GH excess (acromegaly) and by GH deficiency in adult hypopituitary patients. In both acromegaly and adult GH deficiency, there is also increased cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Finally, the status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed in this article.
在这篇综述中，讨论了生长激素 (GH) 对维持成年人心血管功能正常的重要性。涵盖了 GH 的生理作用以及 GH 与胰岛素样生长因子 I (IGF-I) 和心血管系统相互作用的潜在机制，以及 GH 过多（肢端肥大症）和成年垂体功能减退患者 GH 缺乏引起的心脏功能障碍。在肢端肥大症和成年 GH 缺乏症中，心血管发病率和死亡率也增加，这可能与 GH 状态的异常有关。最后，本文还回顾了 GH/IGF-I 系统与心力衰竭的关系以及 GH 作为心力衰竭治疗的一种治疗工具的潜力。
