bin Hussein Mohd Zobir, Zainal Zulkarnain, Yahaya Asmah Hj, Foo Dickens Wong Vui
Multifunctional Nanomaterials for Industrial Application (MULIA) Research Group, Department of Chemistry, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
J Control Release. 2002 Aug 21;82(2-3):417-27. doi: 10.1016/s0168-3659(02)00172-4.
Formation of the so-called organic-inorganic nanohybrid material was exploited for the preparation of a controlled release formulation. The inorganic Zn-Al-layered double hydroxide (LDH) was used as a matrix, hosting an active agent or a guest, alpha-naphthaleneacetate (NAA), a plant growth regulator by self-assembly technique. The reverse process, i.e., the deintercalation or release of the guest, NAA was found to be rapid initially, followed by a more sustained release thereafter and this behavior was dependent on the pH of the release medium, the aqueous solution. The mechanism of release has been interpreted on the basis of the ion-exchange process between the NAA anion intercalated in the lamella host and nitrate or hydroxyl anions in the aqueous solution.
利用所谓的有机-无机纳米杂化材料的形成来制备控释制剂。无机锌铝层状双氢氧化物（LDH）用作基质，通过自组装技术容纳活性剂或客体α-萘乙酸（NAA），一种植物生长调节剂。发现客体NAA的脱嵌或释放的反向过程最初很快，随后释放更加持续，并且这种行为取决于释放介质（水溶液）的pH值。基于插层在层状主体中的NAA阴离子与水溶液中的硝酸根或氢氧根阴离子之间的离子交换过程解释了释放机制。
