Chan L, Jin Y, Heng P
Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, S (117543), Singapore, Singapore.
Int J Pharm. 2002 Aug 21;242(1-2):255-8. doi: 10.1016/s0378-5173(02)00169-2.
Calcium chloride and zinc sulphate were used to cross-link alginate microspheres prepared by an emulsification method. The microspheres cross-linked by a combination of these two salts showed different morphology and slower drug release compared with those cross-linked by the calcium salt alone. From viscosity study, it was found that zinc cations interacted with the alginate molecules to a greater extent than calcium cations. The varying effects of the salts on the properties of the microspheres were largely attributed to their ability to interact with the alginate molecules.
氯化钙和硫酸锌被用于交联通过乳化法制备的海藻酸盐微球。与仅用钙盐交联的微球相比，由这两种盐组合交联的微球呈现出不同的形态且药物释放更慢。通过粘度研究发现，锌阳离子与海藻酸盐分子的相互作用程度比钙阳离子更大。盐对微球性质的不同影响很大程度上归因于它们与海藻酸盐分子相互作用的能力。
