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Rapamycin blocks the generation of regulatory T cells facilitated by posttransplant infusion of donor T cells through increasing the apoptosis of thymic CD4(+)CD25(+) cells.

作者信息

Tsui Tung-Yu, Lau C-K, Schlitt H J, Fan S-T

机构信息

Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road 102, Hong Kong, China.

出版信息

Transplant Proc. 2002 Aug;34(5):1390-1. doi: 10.1016/s0041-1345(02)03067-1.

DOI:10.1016/s0041-1345(02)03067-1
PMID:12176409
Abstract
摘要

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1
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Role of thymic- and graft-dependent mechanisms in tolerance induction to rat kidney transplant by donor PBMC infusion.胸腺依赖性和移植物依赖性机制在通过供体外周血单个核细胞输注诱导大鼠肾移植耐受中的作用。
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