Agarwal R, Peters T J, Coombes R C, Vigushin D M
Section of Medicine, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Med Oncol. 2002;19(2):121-3. doi: 10.1385/MO:19:2:121.
We report a case of porphyria cutanea tarda (PCT) in a patient with breast cancer following adjuvant tamoxifen. Cessation of tamoxifen resulted in a prompt decline in urinary porphyrins suggestive of a causative role. Tamoxifen is known to be hepatotoxic; however, its association with PCT is unclear. In this report, we discuss the porphyrinogenicity of tamoxifen and potential mechanisms.
我们报告了一例在辅助使用他莫昔芬治疗乳腺癌的患者中发生迟发性皮肤卟啉症（PCT）的病例。停用他莫昔芬后，尿卟啉迅速下降，提示其致病作用。已知他莫昔芬具有肝毒性；然而，其与PCT的关联尚不清楚。在本报告中，我们讨论了他莫昔芬的致卟啉生成作用及潜在机制。
