MacGillivray Megan E, Salopek Thomas G
Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Case Rep Dermatol. 2018 May 17;10(2):115-121. doi: 10.1159/000488899. eCollection 2018 May-Aug.
Porphyria cutanea tarda (PCT) is a cutaneous porphyria that presents later in life with cutaneous findings in sun-exposed sites. We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins. While on chloroquine she developed extensive classic vitiligo. It is not clear if this is another feature of her complex and unusual PCT, or a consequence of her antimalarial therapy.
迟发性皮肤卟啉症（PCT）是一种皮肤卟啉症，在生命后期出现，在阳光暴露部位有皮肤表现。我们报告了一例67岁女性的复杂PCT病例，其具有一系列不寻常的皮肤表现：硬皮病、获得性鱼鳞病和非瘢痕性脱发。她患PCT的可能诱因包括乳腺癌的他莫昔芬治疗和血色素沉着症基因的携带者状态。高剂量氯喹成功实现了临床缓解并使她的尿卟啉水平恢复正常。在服用氯喹期间，她出现了广泛的典型白癜风。尚不清楚这是她复杂且不寻常的PCT的另一特征，还是抗疟治疗的结果。
