Runciman D J, Lee A M, Reed K F M, Walsh J R
Maffra Veterinary Centre, Victoria.
Aust Vet J. 2002 Jan-Feb;80(1-2):28-32. doi: 10.1111/j.1751-0813.2002.tb12041.x.
A diagnosis of dicoumarol toxicity in a herd of Friesian cattle was made following investigation of the deaths of three mature cows and eleven yearling heifers. Affected stock had been fed wrapped, bailed silage containing approximately 90% sweet vernal grass (Anthoxanthum odoratum). Sweet vernal grass contains coumarin, which can be converted to dicoumarol, a vitamin K antagonist, through the action of moulds. Most deaths were preceded by lethargy, severe anaemia and subcutaneous and internal haemorrhage. Dicoumarol toxicosis was suspected based on clinical signs, necropsy findings and prolonged prothrombin and activated partial thromboplastin times. Dicoumarol analysis of blood from affected animals and silage confirmed the diagnosis. Activated partial thromboplastin time Haemoglobin Packed cell volume Prothrombin time Red cell count
在对3头成年母牛和11头一岁小母牛死亡事件进行调查后，确诊了一群弗里斯兰奶牛发生双香豆素中毒。受影响的牲畜食用了包装好的、打成捆的青贮饲料，其中约90%是香茅草（Anthoxanthum odoratum）。香茅草含有香豆素，通过霉菌的作用可转化为双香豆素，一种维生素K拮抗剂。大多数死亡之前都有嗜睡、严重贫血以及皮下和内出血症状。根据临床症状、尸检结果以及凝血酶原时间和活化部分凝血活酶时间延长，怀疑是双香豆素中毒。对受影响动物的血液和青贮饲料进行双香豆素分析证实了诊断。活化部分凝血活酶时间、血红蛋白、血细胞比容、凝血酶原时间、红细胞计数
