Shinto Osamu, Yashiro Masakazu, Yamada Nobuya, Matsuoka Tasuku, Ohira Masaichi, Ishikawa Tetsuro, Nishino Hiroji, Hirakawa Kosei
Department of Surgical Oncology (First Department of Surgery), Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Japan.
Surg Today. 2002;32(8):716-9. doi: 10.1007/s005950200133.
We describe herein a case of primary leiomyosarcoma of the breast in a 59-year-old woman. Preoperative clinical examination and cytology findings indicated a benign breast tumor, but intraoperative histopathological examination of the tumor revealed malignant spindle cells, and a modified radical mastectomy was performed. Immunohistochemical analysis subsequently confirmed a diagnosis of leiomyosarcoma. Primary leiomyosarcoma of the breast is extremely rare and difficult to diagnose before surgery because of the need for mitotic figures and immunohistochemical staining to confirm the diagnosis. When pre- and intraoperative examinations indicate the possibility of a leiomyosarcoma, an extended excision with sufficient margins should be performed to remove all of the affected tissue. A review of the literature on this unusual tumor of the breast is presented.
我们在此描述一例59岁女性原发性乳腺平滑肌肉瘤的病例。术前临床检查和细胞学检查结果提示为良性乳腺肿瘤，但术中对肿瘤进行组织病理学检查发现恶性梭形细胞，遂行改良根治性乳房切除术。随后免疫组化分析确诊为平滑肌肉瘤。原发性乳腺平滑肌肉瘤极为罕见，术前难以诊断，因为需要有丝分裂象和免疫组化染色来确诊。当术前和术中检查提示有平滑肌肉瘤的可能时，应进行切缘足够的扩大切除，以切除所有受累组织。本文对有关这种不常见乳腺肿瘤的文献进行了综述。
