Dil'man V M, Anisimov V N
Biull Eksp Biol Med. 1975 Nov;80(11):96-8.
Daily treatment of hemicastrated young rats with 0.57 mug of stilbestrol inhibited compensatory ovarian hypertrophy (COH) by 48% in the 3-month animals and by 3% only in the 18-month animals. Administration of L-DOPA, dilantin, epithalamin or phenoformin with the same dose of estrogen to old rats suppressed the COH by 65-98%. L-DOPA and epithalamin were effective when administered into the 3rd cerebral ventricle. A functional nature of the age changes in the hypothalamic sensitivity to the estrogen action is suggested.
用0.57微克己烯雌酚每日治疗半阉割幼鼠，可使3月龄动物的代偿性卵巢肥大（COH）抑制48%，而在18月龄动物中仅抑制3%。给老年大鼠施用相同剂量雌激素时同时给予左旋多巴、苯妥英、表硫胺素或苯乙双胍，可使COH抑制65%-98%。将左旋多巴和表硫胺素注入第三脑室时有效。提示下丘脑对雌激素作用的敏感性存在年龄变化的功能性本质。
