Anisimov V N
Endokrinologie. 1978 Apr;71(2):149-53.
Treatment of hemicastrated adult female rats with nicotine increased the compensatory ovarian hypertrophy (COH) while central n-cholinolytic IEM-506 decreased COH and prevented the estrogen-induced suppression of COH. Administration of L-DOPA abolished the effect of IEM-506, and disulfiram blocked gonadotropic action of nicotine. Elevation of the dose of arecoline decreased COH and the sensitivity of hypothalamo-gonadotropic complex to estrogen suppression. Treatment of rats with L-DOPA and disulfiram abolished the late effect of arecoline. Central m-cholinolytic metamizyl decreased COH, potentiated the effect of estrogen and prevented the gonadotropic effect of L-DOPA. The regulatory role of m-cholinergic systems in noradrenaline mediation of gonadotropic function and n-cholinergic system in dopamine ones are suggested.
用尼古丁处理成年半阉割雌性大鼠会增加代偿性卵巢肥大（COH），而中枢性N - 胆碱能阻断剂IEM - 506会降低COH并防止雌激素诱导的COH抑制。给予左旋多巴消除了IEM - 506的作用，而双硫仑阻断了尼古丁的促性腺作用。增加槟榔碱剂量会降低COH以及下丘脑 - 促性腺复合体对雌激素抑制的敏感性。用左旋多巴和双硫仑处理大鼠消除了槟榔碱的后期作用。中枢性M - 胆碱能阻断剂安乃近降低了COH，增强了雌激素的作用并防止了左旋多巴的促性腺作用。提示M - 胆碱能系统在去甲肾上腺素介导的促性腺功能中以及N - 胆碱能系统在多巴胺介导的促性腺功能中具有调节作用。
