在包囊形成过程中，单个蓝氏贾第鞭毛虫滋养体中不同变体特异性表面蛋白的同时表达。
Simultaneous expression of different variant-specific surface proteins in single Giardia lamblia trophozoites during encystation.
作者信息
Carranza Pedro G, Feltes Gisela, Ropolo Andrea, Quintana Silvia M C, Touz María C, Luján Hugo D
机构信息
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, CP 5000 Córdoba, Argentina.
出版信息
Infect Immun. 2002 Sep;70(9):5265-8. doi: 10.1128/IAI.70.9.5265-5268.2002.
Abstract
A novel variant-specific surface protein (VSP) from Giardia was identified using the monoclonal antibody 9B10, raised against purified cyst walls. VSP9B10B is preferentially induced during encystation and expressed simultaneously with other VSPs on the surface of encysting trophozoites. These results support the hypothesis that encystation and antigenic variation are processes that are mechanistically related.
摘要
利用针对纯化包囊壁产生的单克隆抗体9B10，鉴定出一种来自贾第虫的新型变体特异性表面蛋白（VSP）。VSP9B10B在包囊形成过程中优先被诱导，并与其他VSP同时在包囊滋养体表面表达。这些结果支持了包囊形成和抗原变异在机制上相关的假说。
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