从皮肤损伤处分离出的家猫乳头瘤病毒与犬口腔乳头瘤病毒有关，并且在E2和L2开放阅读框之间含有一个1.3 kb的非编码区。

Felis domesticus papillomavirus, isolated from a skin lesion, is related to canine oral papillomavirus and contains a 1.3 kb non-coding region between the E2 and L2 open reading frames.

作者信息

Terai Masanori, Burk Robert D

机构信息

Department of Microbiology & Immunology1, and Departments of Pediatrics, Obstetrics & Gynecology and Women's Health, and Epidemiology & Social Medicine2, Comprehensive Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

出版信息

J Gen Virol. 2002 Sep;83(Pt 9):2303-2307. doi: 10.1099/0022-1317-83-9-2303.

DOI:10.1099/0022-1317-83-9-2303

PMID:12185286

Abstract

We have characterized the complete genome (8300 bp) of an isolate of Felis domesticus papillomavirus (FdPV) from a domestic cat with cutaneous papillomatosis. A BLAST homology search using the nucleotide sequence of the L1 open reading frame demonstrated that the FdPV genome was most closely related to canine oral papillomavirus (COPV). A 384 bp non-coding region (NCR) was found between the end of L1 and the beginning of E6, and a 1.3 kbp NCR was located between the end of E2 and the beginning of L2. Phylogenetic analysis placed FdPV in the E3 clade with COPV. Both viruses contain the atypical second NCR, which has no homology with sequences in existing databases.

摘要

我们对一株来自患有皮肤乳头瘤病的家猫的家猫乳头瘤病毒（FdPV）分离株的完整基因组（8300 bp）进行了特征分析。使用L1开放阅读框的核苷酸序列进行的BLAST同源性搜索表明，FdPV基因组与犬口腔乳头瘤病毒（COPV）关系最为密切。在L1末端和E6起始端之间发现了一个384 bp的非编码区（NCR），在E2末端和L2起始端之间定位了一个1.3 kbp的NCR。系统发育分析将FdPV与COPV一起置于E3进化枝中。两种病毒都含有非典型的第二个NCR，它与现有数据库中的序列没有同源性。