Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA; Washington Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Vet Microbiol. 2014 Jan 10;168(1):214-20. doi: 10.1016/j.vetmic.2013.11.011. Epub 2013 Nov 15.
The papillomaviruses comprise a large group of viruses that cause proliferations of the stratified squamous epithelium of skin and mucosa in a variety of animals. An earlier report identified a novel papillomavirus of the North American beaver, Castor canadensis (CcanPV1) that was associated with cutaneous exophytic lesions. In the current study, we determined the sequence of the complete 7435 basepair genome of CcanPV1. The genome contains an Upstream Regulatory Region located between the end of L1 and the start of E6, and seven canonical papillomavirus open reading frames encoding five early (E6, E7, E1, E2, and E4) and two late (L2 and L1) proteins. No E5 open reading frame was detected. Phylogenetic analysis of the CcanPV1 genome places the virus between the genera Kappapapillomavirus and Mupapillomavirus. Analyses of the papillomavirus genomes detected in different species of the order Rodentia indicate these viruses do not form a monophyletic clade.
乳头瘤病毒是一组能引起多种动物皮肤和黏膜的复层鳞状上皮增生的病毒。先前的一份报告确定了一种与北美海狸（Castor canadensis）皮肤外生性病变相关的新型乳头瘤病毒，即加拿大海狸乳头瘤病毒 1 型（CcanPV1）。在本研究中，我们测定了 CcanPV1 全长 7435 个碱基对基因组的序列。该基因组包含一个位于 L1 末端和 E6 起始之间的上游调控区，以及七个经典的乳头瘤病毒开放阅读框，编码五个早期（E6、E7、E1、E2 和 E4）和两个晚期（L2 和 L1）蛋白。未检测到 E5 开放阅读框。CcanPV1 基因组的系统发育分析将该病毒置于 Kappapapillomavirus 和 Mupapillomavirus 属之间。对啮齿目不同物种中检测到的乳头瘤病毒基因组的分析表明，这些病毒并未形成一个单系进化枝。
