Sato H, Doi M, Okuno T
Brain Dev. 1979;1(2):97-102. doi: 10.1016/s0387-7604(79)80017-0.
The efficacy, serum concentration and side effects of CBZ for partial seizures in children were evaluated. The study was undertaken on 27 patients with partial seizures ranging from 5 to 17 years of age. Further 15 patients with various types of epilepsy taking CBZ with other anticonvulsants were selected as controls to compare the serum levels of CBZ. In nineteen of the 27 patients seizures were controlled completely, in whom serum CBZ levels varied fro trace to 15.6 mcg/ml, average being 8.18 +/- 3.40 mcg/ml, while those of uncontrolled ones ranged from 3.5 to 11.3 mcg/ml, average being 7.50 +/- 2.97 mcg/ml. There was no significant difference between both groups of the above. EEG was improved in the seven of 19 seizure-free cases, serum levels of which ranged from 5.9 to 13.2 mcg/ml. With regard to the side effects, transient leucopenia was observed in four patients and serum GOT and GPT slightly elevated in two. Correlation between dose and serum level in the monotherapy group was not significant as well as in the combined therapy group. Serum DBZ levels in the monotherapy group were significantly higher than those in combined therapy group.
评估了卡马西平（CBZ）治疗儿童部分性发作的疗效、血清浓度及副作用。该研究对27例年龄在5至17岁的部分性发作患儿进行。另外选取15例服用CBZ及其他抗惊厥药物的各类癫痫患者作为对照，以比较CBZ的血清水平。27例患者中有19例发作完全得到控制，其血清CBZ水平从微量到15.6微克/毫升不等，平均为8.18±3.40微克/毫升，而未得到控制的患者血清CBZ水平在3.5至11.3微克/毫升之间，平均为7.50±2.97微克/毫升。上述两组之间无显著差异。19例无发作病例中有7例脑电图有所改善，其血清水平在5.9至13.2微克/毫升之间。关于副作用，4例患者出现短暂性白细胞减少，2例患者血清谷草转氨酶（GOT）和谷丙转氨酶（GPT）略有升高。单药治疗组和联合治疗组中剂量与血清水平之间均无显著相关性。单药治疗组的血清二苯乙内酰脲（DBZ）水平显著高于联合治疗组。
