Hazlet Thomas K, Blough David K
Pharmaceutical Outcomes Research and Policy Program, School of Pharmacy, University of Washington, Seattle, WA 98195-7630, USA.
Med Care. 2002 Aug;40(8):640-9. doi: 10.1097/00005650-200208000-00003.
In October 1995, British Columbia introduced a reference pricing policy for five therapeutic classes of drugs, including histamine(2) receptor antagonists (H(2)RAs), for beneficiaries of its prescription drug program, Pharmacare.
To evaluate utilization trends in consumption of health services in a cohort of Pharmacare beneficiaries to determine if a worsening of health outcomes could be detected after implementation of the reference pricing policy.
Two cohorts, "control" (21 months before the reference pricing policy) and "exposed" (at risk for policy effects), were followed for 21 months. Using a longitudinal generalized linear model (Poisson), and controlling for age, sex, and prescriptions in unique drug classes, trend lines in each of these time series were compared for 3 periods: 9 months before policy implementation (or corresponding index date in the control cohort), 6 months after policy implementation, and a subsequent 6-month period.
Two cohorts, each of size 10,000, were constructed by randomly sampling the population of Pharmacare beneficiaries exposed to H(2)RAs and other antisecretory drugs for 1993 through 1996.
Prescriptions, physician office visits and associated transactions (ie, laboratory tests), emergency room visits, hospitalizations, hospital length of stay, and vital statistics.
Differences between periods and between cohorts for health services utilization were not significant or decreased after imposition of the reference pricing policy.
For these measures, there has been no worsening of health outcomes associated with implementing the reference pricing policy.
1995年10月,不列颠哥伦比亚省为其处方药计划“药物关爱计划”(Pharmacare)的受益者引入了针对五类治疗药物的参考定价政策,其中包括组胺(2)受体拮抗剂(H₂RAs)。
评估药物关爱计划受益者队列中医疗服务消费的使用趋势,以确定在实施参考定价政策后是否能检测到健康结果的恶化。
对两个队列进行了为期21个月的跟踪,一个“对照组”(参考定价政策实施前21个月)和一个“暴露组”(有政策影响风险)。使用纵向广义线性模型(泊松分布),并控制年龄、性别和独特药物类别中的处方数量,比较了这两个时间序列在三个时间段的趋势线:政策实施前9个月(或对照组的相应索引日期)、政策实施后6个月以及随后的6个月期间。
通过随机抽取1993年至1996年接触H₂RAs和其他抗分泌药物的药物关爱计划受益者人群,构建了两个各有10000人的队列。
处方、医生门诊就诊及相关诊疗项目(即实验室检查)、急诊就诊、住院、住院时长以及人口动态统计数据。
实施参考定价政策后,各时间段之间以及队列之间在医疗服务利用方面的差异不显著或有所减少。
就这些测量指标而言,实施参考定价政策并未导致健康结果恶化。