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药物费用分担对接受抗抑郁药治疗的老年人服务利用及不良临床结局的影响。

Impact of drug cost sharing on service use and adverse clinical outcomes in elderly receiving antidepressants.

作者信息

Wang Philip S, Patrick Amanda R, Dormuth Colin, Maclure Malcolm, Avorn Jerry, Canning Claire F, Schneeweiss Sebastian

机构信息

National Institute of Mental Health, 6001 Executive Blvd., Room 8229, MSC 9669, Bethesda, MD 20892, USA.

出版信息

J Ment Health Policy Econ. 2010 Mar;13(1):37-44.

Abstract

BACKGROUND

Depression imposes enormous burdens on the elderly. Despite this, rates of initiation of and adherence to recommended pharmacotherapy are frequently low in this population. Although initiatives such as the Medicare Modernization Act (MMA) have improved seniors' access to antidepressants, there are concerns that the patient cost-sharing incorporated in the MMA may have unintended consequences if it reduces essential drug use. Age-related pharmacokinetic and pharmacodynamic changes could make seniors particularly vulnerable to antidepressant regimens used inappropriately to save costs, increasing their risks of morbidity, hospitalizations, and nursing home placements. Two sequential large-scale "natural experiments'' in British Columbia provide a unique opportunity to evaluate the effect of cost sharing on outcomes and mental health service use among seniors. In January 2002 the province introduced a CAD 25 copay (CAD10 for low-income seniors). In May 2003 this copay policy was replaced by a second policy consisting of an income-based deductible, 25% coinsurance once the deductible was met, and full coverage once an out-of-pocket ceiling was met. The transition between the two policies is analogous to what many U.S. seniors experience when they transition from private insurance requiring copays to Medicare Part D requiring deductibles and coinsurance.

AIMS

To evaluate whether declines in antidepressant initiation after the introduction of two drug cost-sharing policies in British Columbia were associated with increased use of physician services, hospitalizations, and nursing home admissions among all British Columbia residents aged 65+.

METHODS

Records of physician service use, inpatient hospitalizations, and residential care admissions were obtained from administrative databases. Population-level patterns over time were plotted, and effects of implementing the cost-sharing policies examined in segmented linear regression models.

RESULTS

Neither policy affected the rates of visits to physicians or psychiatrists for depression, hospitalizations with a depression diagnosis, or long-term care admissions.

DISCUSSION

The cost-sharing policies studied may have contained non-essential antidepressant use without substantially increasing mental health service utilization. However, it is possible that the policies had effects that we were unable to detect, such as increasing rates of visits to social workers or psychologists or forcing patients to reduce other spending. Further, the sequential implementation of the policy changes, makes it difficult to estimate the effect of a direct change from full coverage to a coinsurance/income-based deductible policy.

IMPLICATIONS FOR HEALTH POLICIES

It may be possible to design policies to contain non-essential antidepressant use without substantially increasing other service utilization or adverse events. However, because undertreatment remains a serious problem among depressed elderly, well-designed prescription drug policies should be coupled with interventions to address under-treatment.

摘要

背景

抑郁症给老年人带来了巨大负担。尽管如此,在这一人群中,推荐药物治疗的起始率和依从率通常较低。尽管诸如《医疗保险现代化法案》(MMA)等举措改善了老年人获得抗抑郁药的机会,但人们担心,如果MMA中纳入的患者费用分摊降低了基本药物的使用,可能会产生意想不到的后果。与年龄相关的药代动力学和药效学变化可能使老年人特别容易受到为节省成本而不当使用抗抑郁治疗方案的影响,从而增加他们发病、住院和入住养老院的风险。不列颠哥伦比亚省的两项连续大规模“自然实验”提供了一个独特的机会,来评估费用分摊对老年人的治疗结果和心理健康服务使用的影响。2002年1月,该省引入了25加元的自付费用(低收入老年人为10加元)。2003年5月,这一自付费用政策被另一项政策取代,该政策包括基于收入的免赔额、达到免赔额后25%的共保费用以及达到自付费用上限后的全额覆盖。这两项政策之间的转变类似于许多美国老年人从需要自付费用的私人保险过渡到需要免赔额和共保费用的医疗保险D部分时所经历的情况。

目的

评估不列颠哥伦比亚省实施两项药物费用分摊政策后抗抑郁药起始率的下降是否与该省所有65岁以上居民使用医生服务、住院和入住养老院的增加有关。

方法

从行政数据库中获取医生服务使用、住院治疗和住院护理记录。绘制随时间变化的人群水平模式,并在分段线性回归模型中检验实施费用分摊政策的效果。

结果

两项政策均未影响因抑郁症就诊于医生或精神科医生的比例、诊断为抑郁症的住院率或长期护理入住率。

讨论

所研究的费用分摊政策可能抑制了不必要的抗抑郁药使用,而没有大幅增加心理健康服务的利用率。然而,这些政策有可能产生了我们无法检测到的影响,例如增加了拜访社会工作者或心理学家的次数,或者迫使患者减少其他开支。此外,政策变化的相继实施使得难以估计从全额覆盖直接转变为基于共保/收入免赔额政策的影响。

对卫生政策的启示

有可能设计出既能抑制不必要的抗抑郁药使用,又不会大幅增加其他服务利用率或不良事件的政策。然而,由于治疗不足在老年抑郁症患者中仍然是一个严重问题,精心设计的处方药政策应与解决治疗不足的干预措施相结合。

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Psychiatr Serv. 2008 Apr;59(4):377-83. doi: 10.1176/ps.2008.59.4.377.
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Unintended consequences of caps on Medicare drug benefits.
N Engl J Med. 2006 Jun 1;354(22):2349-59. doi: 10.1056/NEJMsa054436.
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Suboptimal antidepressant use in the elderly.
J Clin Psychopharmacol. 2005 Apr;25(2):118-26. doi: 10.1097/01.jcp.0000155819.67209.e5.
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Clinical and economic consequences of reference pricing for dihydropyridine calcium channel blockers.
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