Wang S-J, Lan J-L, Lan J-L, Chen D-Y, Chen Y-H, Hsieh T-Y, Lin W-Y
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Clin Rheumatol. 2002 Aug;21(4):271-4. doi: 10.1007/s100670200072.
Progressive systemic sclerosis (PSS) may involve any portion of the gastrointestinal tract, including the colon. Constipation is common in patients with PSS. Cisapride, a benzamide derivative, is a potentially useful agent in the treatment of chronic idiopathic constipation. The effect of cisapride on colonic transit was evaluated in 16 PSS patients by a radionuclide colonic transit method. Each patient received cisapride orally three times a day for a week. The results showed acceleration in colonic transit in response to cisapride. We conclude that cisapride is effective in the treatment of constipation in patients with PSS.
进行性系统性硬化症（PSS）可能累及胃肠道的任何部分，包括结肠。便秘在PSS患者中很常见。西沙必利是一种苯甲酰胺衍生物，是治疗慢性特发性便秘的一种潜在有效药物。通过放射性核素结肠运输法对16例PSS患者评估了西沙必利对结肠运输的影响。每位患者每天口服西沙必利三次，共一周。结果显示，西沙必利可使结肠运输加速。我们得出结论，西沙必利对治疗PSS患者的便秘有效。
