煤烟色猕猴中甲型疱疹病毒感染的血清学证据。

Serological evidence of alpha herpesvirus infection in sooty mangabeys.

作者信息

Henkel R D, McClure H M, Krug P, Katz D, Hilliard J K

机构信息

Viral Immunology Center, Georgia State University, Atlanta, GA, USA.

出版信息

J Med Primatol. 2002 Jun;31(3):120-8. doi: 10.1034/j.1600-0684.2002.01033.x.

DOI:10.1034/j.1600-0684.2002.01033.x

PMID:12190852

Abstract

Contact between sooty mangabeys (SMs) and a pigtailed macaque prompted the serological screening of SMs for evidence of infection with B virus. Serological tests detected SM antibodies that reacted with B virus polypeptides. Additional testing was performed with sera from SMs with no previous contact with macaques. Results from these tests indicated that 56% (33/59) of the SMs had antibodies that reacted with B virus and SA8. SM antibodies also reacted with herpesvirus papio 2 and to a lesser extent with human alpha herpesviruses (HSV-1 and HSV-2). There was an age-related increase in the presence of these antibodies in SMs that was consistent with the serological pattern of reactivity observed in other nonhuman primate species infected with alpha herpesviruses. These data suggest that SMs may be a host for a herpesvirus that is antigenically similar to those viruses present in other Old World nonhuman primates.

摘要

乌黑白眉猴（SMs）与豚尾猕猴的接触促使对乌黑白眉猴进行血清学筛查，以寻找感染B病毒的证据。血清学检测发现乌黑白眉猴抗体与B病毒多肽发生反应。对之前未接触过猕猴的乌黑白眉猴血清进行了额外检测。这些检测结果表明，56%（33/59）的乌黑白眉猴具有与B病毒和SA8发生反应的抗体。乌黑白眉猴抗体也与狒狒疱疹病毒2发生反应，且与人类α疱疹病毒（HSV-1和HSV-2）的反应程度较低。在乌黑白眉猴中，这些抗体的存在呈现与年龄相关的增加，这与在感染α疱疹病毒的其他非人灵长类动物中观察到的血清学反应模式一致。这些数据表明，乌黑白眉猴可能是一种疱疹病毒的宿主，该病毒在抗原性上与其他旧世界非人灵长类动物中存在的病毒相似。