Gianetti J, Bevilacqua S, De Caterina R
Ospedale G. Pasquinucci, CNR Institute of Clinical Physiology and G. d'Annunzio University, Chieti, Italy.
Eur J Clin Invest. 2002 Aug;32(8):628-35. doi: 10.1046/j.1365-2362.2002.01049.x.
Because of its high diffusing capacity through the alveolar-blood barrier and its high selectivity for the pulmonary vasculature, inhaled nitric oxide (NO) has been recently shown to be a viable and efficient approach to restore pulmonary NO deficiency. The most relevant applications of inhaled NO are in infants with primary pulmonary hypertension or hypoxia. In these patients, inhaled NO improves gas exchange and ventilation-perfusion matching, reduces the length of hospitalization and is without severe detrimental effects. The use of inhaled NO has also been extended to adults with pulmonary hypertension and the acute respiratory distress syndrome. In addition, recent clinical evidence supported by data from animal models, shows beneficial extra-pulmonary effects of inhaled NO, including protection against myocardial ischaemia-reperfusion injury.
由于一氧化氮（NO）通过肺泡-血液屏障的高扩散能力及其对肺血管系统的高选择性，最近已证明吸入一氧化氮是恢复肺部一氧化氮缺乏的一种可行且有效的方法。吸入一氧化氮最相关的应用是在患有原发性肺动脉高压或低氧血症的婴儿中。在这些患者中，吸入一氧化氮可改善气体交换和通气-灌注匹配，缩短住院时间且无严重不良影响。吸入一氧化氮的应用也已扩展到患有肺动脉高压和急性呼吸窘迫综合征的成人。此外，动物模型数据支持的最新临床证据表明，吸入一氧化氮具有有益的肺外效应，包括对心肌缺血-再灌注损伤的保护作用。
