Blokesch M, Paschos A, Theodoratou E, Bauer A, Hube M, Huth S, Böck A
Department Biologie I, Mikrobiologie, Universität München, Maria-Ward-Strasse 1a, D-80638 München, Germany.
Biochem Soc Trans. 2002 Aug;30(4):674-80. doi: 10.1042/bst0300674.
The synthesis and the insertion of the metallocentre of NiFe-hydrogenases is a complex process, in which seven maturation enzymes plus ATP, GTP and carbamoyl phosphate are involved. The review summarizes what is known about the properties and activities of these auxiliary proteins, and postulates a pathway along which maturation may take place.
镍铁氢化酶金属中心的合成与插入是一个复杂的过程,其中涉及七种成熟酶以及ATP、GTP和氨基甲酰磷酸。这篇综述总结了关于这些辅助蛋白的性质和活性的已知信息,并推测了可能发生成熟的途径。