Daniele N, Halse R, Grinyo E, Yeaman S J, Shepherd P R
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
Biochem Soc Trans. 2002 Aug;30(4):800-2. doi: 10.1042/bst0300800.
There is an increasing emphasis on the need for high-quality biological data much earlier in the drug-discovery process. This has led to the development of high-throughput approaches to biology, many of which rely on the use of cell-culture models. Unfortunately, available cell-culture models often reflect poorly the characteristics of the tissue they are supposed to represent. However, the conditional-immortalization approach as applied by Xcellsyz offers the possibility of producing human cell lines on demand, which are truly representative of the tissue from which they derive.
在药物发现过程的早期阶段，对高质量生物学数据的需求日益增加。这推动了高通量生物学方法的发展，其中许多方法依赖于细胞培养模型的使用。不幸的是，现有的细胞培养模型往往不能很好地反映它们所代表的组织的特征。然而，Xcellsyz应用的条件永生化方法提供了按需生产人类细胞系的可能性，这些细胞系真正代表了它们所源自的组织。
