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本文引用的文献

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Computation of identity by descent probabilities conditional on DNA markers via a Monte Carlo Markov Chain method.通过蒙特卡罗马尔可夫链方法计算基于DNA标记的同源概率。
Genet Sel Evol. 2000 Sep-Oct;32(5):467-82. doi: 10.1186/1297-9686-32-5-467.
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Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders.《人类孟德尔遗传在线》（OMIM），一个人类基因和遗传疾病知识库。
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The Ensembl genome database project.Ensembl基因组数据库项目。
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Identification of genomic regions controlling plasma FSH concentrations in Meishan-White Composite boars.梅山-大白杂交公猪中控制血浆促卵泡素浓度的基因组区域的鉴定。
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A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. II. Meat and muscle composition.一项用于识别影响猪经济性状的染色体区域的分子基因组扫描分析。II. 肉和肌肉组成。
Mamm Genome. 2001 Aug;12(8):637-45. doi: 10.1007/s003350020019.
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A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. I. Growth and body composition.一项用于识别影响猪经济性状的染色体区域的分子基因组扫描分析。I. 生长与身体组成。
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Assessment of genetic variation explained by markers for wool traits in sheep via a segment mapping approach.
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Detection of quantitative trait loci for growth and fatness in pigs.猪生长和脂肪性状数量性状位点的检测
Genet Sel Evol. 2001 May-Jun;33(3):289-309. doi: 10.1186/1297-9686-33-3-289.
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X-chromosome inactivation: counting, choice and initiation.X染色体失活：计数、选择与起始
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Mapping quantitative trait loci in complex pedigrees: a two-step variance component approach.复杂家系中数量性状基因座的定位：一种两步方差成分法。
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探索远交群体中与性别相关的数量性状基因座的替代模型：应用于伊比利亚猪与地方品种猪的杂交群体

Exploring alternative models for sex-linked quantitative trait loci in outbred populations: application to an iberian x landrace pig intercross.

作者信息

Pérez-Enciso Miguel, Clop Alex, Folch Josep M, Sánchez Armand, Oliver Maria A, Ovilo Cristina, Barragán C, Varona Luis, Noguera José L

机构信息

Centre UdL-IRTA, Area de Producció Animal, 25198 Lleida, Spain.

出版信息

Genetics. 2002 Aug;161(4):1625-32. doi: 10.1093/genetics/161.4.1625.

DOI:10.1093/genetics/161.4.1625
PMID:12196405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1462213/
Abstract

We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breeds, as well as mixed models. Different genetic variances within each founder breed can be estimated. We illustrate the method with data from an F(2) cross between Iberian x Landrace pigs for intramuscular fat content and meat color component a*. The Iberian allele exhibited a strong overdominant effect for intramuscular fat in females. There was also limited evidence of one or more regions affecting color component a*. The analysis suggested that the QTL alleles were fixed in the Iberian founders, whereas there was some evidence of segregation in Landrace for the QTL affecting a* color component.

摘要

我们提出了一种非常灵活的方法，可用于分析远交系之间杂交中的X连锁数量性状基因座（QTL）。在基于系谱的方法中明确对剂量补偿现象进行了建模。可以拟合多种模型，从考虑奠基品种内的替代固定等位基因到仅品种内存在遗传变异的模型，以及混合模型。可以估计每个奠基品种内不同的遗传方差。我们用伊比利亚猪与长白猪杂交的F(2)代中肌内脂肪含量和肉色成分a的数据说明了该方法。伊比利亚等位基因对雌性肌内脂肪表现出强烈的超显性效应。也有有限的证据表明存在一个或多个影响颜色成分a的区域。分析表明，QTL等位基因在伊比利亚奠基品种中是固定的，而对于影响a*颜色成分的QTL，长白猪中存在一些分离的证据。