Sheu B-S, Wu J-J, Lo C-Y, Wu H-W, Chen J-H, Lin Y-S, Lin M-D
Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan.
Aliment Pharmacol Ther. 2002 Sep;16(9):1669-75. doi: 10.1046/j.1365-2036.2002.01335.x.
To test whether supplements of Lactobacillus- and Bifidobacterium-containing yogurt (AB-Yogurt) affect the success of Helicobacter pylori eradication.
One hundred and sixty H. pylori-infected patients were randomized into a triple-plus-yogurt group or a triple-only group, receiving 1 week of triple therapy with and without supplements of AB-Yogurt, respectively. In the triple-plus-yogurt group, AB-Yogurt was continued for 4 weeks after triple therapy. Eight weeks later, patients were assessed for the success of H. pylori eradication. The stool samples of 22 randomly selected patients, 11 from each group, were provided on enrolment, at the first week and at the fifth week for evaluation of the percentage of Bifidobacterium in anaerobes.
By intention-to-treat analysis, the triple-plus-yogurt group had a higher H. pylori eradication rate than the triple-only group (91% vs. 78%, P < 0.05). The per protocol H. pylori eradication rates were similar for both groups (93.5% vs. 89%, P = N.S.). Only patients supplemented with AB-Yogurt showed restoration of the percentage of Bifidobacterium in the anaerobes of stools at the fifth week to the level in the stools on enrolment.
Supplement with AB-Yogurt can improve the intention-to-treat eradication rates of H. pylori, and can restore the depletion of Bifidobacterium in stools after triple therapy.
检测含乳酸杆菌和双歧杆菌的酸奶（AB酸奶）补充剂是否会影响幽门螺杆菌根除的成功率。
160例幽门螺杆菌感染患者被随机分为三联疗法加酸奶组或单纯三联疗法组，分别接受为期1周的含或不含AB酸奶补充剂的三联疗法。在三联疗法加酸奶组中，三联疗法后继续服用AB酸奶4周。8周后，评估患者幽门螺杆菌根除的成功率。在入组时、第1周和第5周，从每组中随机选取11例患者，共22例患者提供粪便样本，以评估厌氧菌中双歧杆菌的百分比。
意向性分析显示，三联疗法加酸奶组的幽门螺杆菌根除率高于单纯三联疗法组（91%对78%，P<0.05）。两组的符合方案分析的幽门螺杆菌根除率相似（93.5%对89%，P=无统计学意义）。只有补充AB酸奶的患者在第5周时粪便厌氧菌中双歧杆菌的百分比恢复到入组时粪便中的水平。
补充AB酸奶可提高意向性分析的幽门螺杆菌根除率，并可恢复三联疗法后粪便中双歧杆菌的减少。
