Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC Gastroenterol. 2021 Oct 20;21(1):388. doi: 10.1186/s12876-021-01977-1.
Helicobacter pylori (H. pylori) is the causative agent of stomach diseases such as duodenal ulcer and gastric cancer, in this regard incomplete eradication of this bacterium has become to a serious concern. Probiotics are a group of the beneficial bacteria which increase the cure rate of H. pylori infections through various mechanisms such as competitive inhibition, co-aggregation ability, enhancing mucus production, production of bacteriocins, and modulating immune response.
In this study, according to the received articles, the anti-H. pylori activities of probiotics were reviewed. Based on studies, administration of standard antibiotic therapy combined with probiotics plays an important role in the effective treatment of H. pylori infection. According to the literature, Lactobacillus casei, Lactobacillus reuteri, Lactobacillus rhamnosus GG, and Saccharomyces boulardii can effectively eradicate H. pylori infection. Our results showed that in addition to decrease gastrointestinal symptoms, probiotics can reduce the side effects of antibiotics (especially diarrhea) by altering the intestinal microbiome.
Nevertheless, antagonist activities of probiotics are H. pylori strain-specific. In general, these bacteria can be used for therapeutic purposes such as adjuvant therapy, drug-delivery system, as well as enhancing immune system against H. pylori infection.
幽门螺杆菌（H. pylori）是十二指肠溃疡和胃癌等胃部疾病的病原体，在这方面，这种细菌的不完全根除已成为一个严重的问题。益生菌是一组有益细菌，通过竞争抑制、共聚集能力、增强黏液产生、产生细菌素和调节免疫反应等多种机制提高 H. pylori 感染的治愈率。
在这项研究中，根据收到的文章，综述了益生菌的抗 H. pylori 活性。基于研究，标准抗生素治疗联合益生菌的给药在有效治疗 H. pylori 感染方面发挥着重要作用。根据文献，干酪乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌 GG 和布拉氏酵母菌可有效根除 H. pylori 感染。我们的结果表明，除了减轻胃肠道症状外，益生菌还可以通过改变肠道微生物群来减少抗生素的副作用（尤其是腹泻）。
然而，益生菌的拮抗活性是 H. pylori 菌株特异性的。总的来说，这些细菌可用于治疗目的，如辅助治疗、药物递送系统以及增强免疫系统对抗 H. pylori 感染。
