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对英国为阿片类药物依赖吸毒者开具二醋吗啡(海洛因)处方的医生的调查。

Survey of doctors prescribing diamorphine (heroin) to opiate-dependent drug users in the United Kingdom.

作者信息

Metrebian Nicky, Carnwath Tom, Stimson Gerry V, Storz Thomas

机构信息

Centre for Research on Drugs and Health Behaviour, Department of Social Science and Medicine, Imperial College of Science, Technology and Medicine, London, UK.

出版信息

Addiction. 2002 Sep;97(9):1155-61. doi: 10.1046/j.1360-0443.2002.00193.x.

Abstract

AIM

To determine the scale and practice of diamorphine (heroin) prescribing for opiate dependence in the United Kingdom in 2000.

DESIGN

Postal survey.

SETTING

England, Scotland and Wales.

PARTICIPANTS

One hundred and eleven of the 164 doctors in the United Kingdom on the Home Office record as holding a licence to prescribe diamorphine (response rate 68%), and 59 of the 108 doctors in the United Kingdom eligible to hold a licence (working in drug clinics), but not doing so (response rate 54%).

MEASUREMENTS

The characteristics of doctors (a) holding a licence and (b) currently prescribing; the number of opiate users receiving a prescription; current treatment delivery, clinical criteria for patient eligibility; and reasons for prescribing or not prescribing diamorphine.

FINDINGS

Seventy of the 111 doctors actually held a licence. While the majority were consultant psychiatrists, five were general practitioners. Forty-six were currently prescribing to 448 patients. The majority of prescribers reported that they had not initiated a prescription for diamorphine but had inherited patients already receiving such a prescription. Most of those who prescribed considered that in selected cases it could produce clinical and social improvement. There were great variations in clinical criteria for patient eligibility, prescribing practice, daily dose prescribed (range 5-1500 mg) and the daily dose-equivalent of 100 mg methadone (range 50-900 mg). Many respondents cited lack of appropriate resources as a reason for not prescribing to more patients. Reasons for non-prescribing varied from lack of resources to little evidence of its effectiveness.

CONCLUSIONS

The prescribing of diamorphine to opiate dependent drug users remains rare in the United Kingdom. Not all eligible doctors seek a licence to prescribe, and not all those with licences actually prescribe it. There is no clear consensus on who should be treated with diamorphine and in what way.

摘要

目的

确定2000年英国用于阿片类药物依赖治疗的二醋吗啡(海洛因)处方开具规模及实际情况。

设计

邮寄问卷调查。

地点

英格兰、苏格兰和威尔士。

参与者

英国内政部记录的164名持有二醋吗啡处方许可的医生中有111名(回复率68%),以及英国108名有资格持有该许可(在戒毒诊所工作)但未持有许可的医生中有59名(回复率54%)。

测量指标

(a)持有许可的医生和(b)当前开具处方的医生的特征;接受处方的阿片类药物使用者数量;当前的治疗方式、患者符合资格的临床标准;以及开具或不开具二醋吗啡处方的原因。

研究结果

111名医生中有70名实际持有许可。虽然大多数是精神科顾问医生,但有5名是全科医生。46名医生目前正在为448名患者开具处方。大多数开处方者报告称,他们并非开始开具二醋吗啡处方,而是接手了已经在接受此类处方治疗的患者。大多数开处方者认为,在某些特定情况下,它可以带来临床和社会状况的改善。在患者符合资格的临床标准、处方开具做法、每日处方剂量(范围为5 - 1500毫克)以及100毫克美沙酮的每日等效剂量(范围为50 - 900毫克)方面存在很大差异。许多受访者表示,缺乏适当资源是未给更多患者开处方的原因。不开具处方的原因各不相同,从缺乏资源到几乎没有其有效性的证据。

结论

在英国,给阿片类药物依赖的吸毒者开具二醋吗啡处方的情况仍然很少见。并非所有符合资格的医生都寻求开具处方的许可,而且并非所有持有许可的医生都实际开具该处方。对于哪些人应该接受二醋吗啡治疗以及以何种方式治疗,目前尚无明确共识。

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