Markstein Michele, Levine Michael
Department of Molecular Cell Biology, Division of Genetics & Development, 401 Barker Hall, University of California, Berkeley, California 94720, USA.
Curr Opin Genet Dev. 2002 Oct;12(5):601-6. doi: 10.1016/s0959-437x(02)00345-3.
Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.
顺式调控DNA控制后生动物发育过程中基因表达的时间和位点。基因表达的变化导致了后生动物身体结构的形态多样化。然而，用于鉴定和表征顺式调控DNA的传统方法很繁琐。在过去的一年里，计算方法已被用于在整个果蝇基因组中鉴定新的顺式DNA。这些方法改变了未来研究中分析顺式DNA的方式，并有望揭示复杂的基因网络。
