Bolt R J, van Weissenbruch M M, Roos J C, Delemarre-van de Waal H A, Cranendonk A, Lafeber H N
Department of Pediatrics, VU University Medical Center, PO Box 7057, NL-1007 MB, Amsterdam, The Netherlands.
Acta Paediatr. 2002;91(7):815-21. doi: 10.1080/08035250213220.
The aim of this study was to study the effect of chronic lung disease (CLD) and dexamethasone treatment on body composition in preterm infants (birthweight < 1500 g). In addition, anthropometric measurement of body composition were compared with dual-energy X-ray absorptiometry (DXA). Fourteen preterm infants with CLD and a comparison group of 18 preterm infants were studied until 3 mo corrected age. CLD infants received approximately 20 kcal kg-1 per day extra nutritional intake during dexamethasone treatment until term. At term no differences were found between CLD and no CLD infants for percentage bone mass (1.4 +/- 0.2 vs 1.4 +/- 0.1%), fat mass (18.7 +/- 4.5 vs 17.4 +/- 3.5%), lean body mass (79.9 +/- 4.6 vs 81.2 +/- 3.5%) or bone mineral density (0.15 +/- 0.02 vs 0.15 +/- 0.01%). At 3 mo corrected age both groups were also similar for bone mass (1.6 +/- 0.1 vs 1.6 +/- 0.2%), fat mass (22.6 +/- 5.5 vs 24.5 +/- 5.7%), lean body mass (75.8 +/- 5.7 vs 74.0 +/- 5.8%) and bone mineral density (0.20 +/- 0.02 vs 0.20 +/- 0.01%). All anthropometric measurements showed a high correlation with body composition. However, calculated fat mass was 56.7 +/- 8.8% lower than fat mass measured with DXA.
Body composition at term and 3 mo corrected age in preterm infants treated with dexamethasone for CLD, who received extra caloric intake until term, did not differ from that in preterm infants without CLD.
本研究旨在探讨慢性肺病（CLD）及地塞米松治疗对出生体重＜1500g的早产儿身体成分的影响。此外，将身体成分的人体测量结果与双能X线吸收法（DXA）进行比较。对14例患有CLD的早产儿和18例早产儿对照组进行研究，直至矫正年龄3个月。CLD患儿在接受地塞米松治疗直至足月期间，每天额外摄入约20kcal/kg的营养物质。足月时，CLD患儿与非CLD患儿在骨量百分比（1.4±0.2对1.4±0.1%）、脂肪量（18.7±4.5对17.4±3.5%）、去脂体重（79.9±4.6对81.2±3.5%）或骨矿物质密度（0.15±0.02对0.15±0.01）方面未发现差异。在矫正年龄3个月时，两组在骨量（1.6±0.1对1.6±0.2%）、脂肪量（22.6±5.5对24.5±5.7%）、去脂体重（75.8±5.7对74.0±5.8%）和骨矿物质密度（0.20±0.02对0.20±0.01）方面也相似。所有人体测量结果均显示与身体成分高度相关。然而，计算得出的脂肪量比用DXA测量的脂肪量低56.7±8.8%。
因CLD接受地塞米松治疗且直至足月都额外摄入热量的早产儿，其足月时及矫正年龄3个月时的身体成分与无CLD的早产儿并无差异。
