Titanji V P, Nkuo-Akenji T, Ntopi W, Djokam R
Department of Life Sciences, University of Buea, South West Province, Cameroon.
Cent Afr J Med. 2001 Jun;47(6):145-9.
To evaluate the state of chloroquine resistant malaria in the South West Province of Cameroon. To estimate the prevalence of different species of Plasmodium in the area.
A cross sectional study.
South West Province of Cameroon.
326 febrile patients.
Chloroquine resistance studies using the WHO seven-day standard in vivo test. Speciation of malaria by polymerase chain reaction. Prevalence of falciparum malaria by light microscopy of thick blood smears.
Prevalence of chloroquine resistance ranged from 4.3 to 13.2%. A total of six cases showed RIII resistance, and three cases showed RII resistance. Plasmodium falciparum was the predominant species, 96.8% of those testing positive for P. falciparum, 6.3% of cases showed mixed infections of P. falciparum and P. malariae. P. ovale accounted for 3% of cases.
P. falciparum resistance to chloroquine may not be on the increase compared to earlier reports from the South West Province. The results have important implications in treatment of malaria in view of the low cost of chloroquine.
评估喀麦隆西南部省份氯喹耐药性疟疾的状况。估计该地区不同疟原虫种类的流行情况。
横断面研究。
喀麦隆西南部省份。
326名发热患者。
采用世界卫生组织七天标准体内试验进行氯喹耐药性研究。通过聚合酶链反应进行疟疾虫种鉴定。通过厚血涂片镜检法检测恶性疟原虫的流行情况。
氯喹耐药率在4.3%至13.2%之间。共有6例显示III级耐药，3例显示II级耐药。恶性疟原虫是主要虫种，恶性疟原虫检测呈阳性的患者中96.8%感染该虫种，6.3%的病例显示恶性疟原虫和间日疟原虫混合感染。卵形疟原虫占病例的3%。
与喀麦隆西南部省份早期报告相比，恶性疟原虫对氯喹的耐药性可能并未增加。鉴于氯喹成本较低，这些结果对疟疾治疗具有重要意义。
