Ueno Kana, Minoguchi Kenji, Kohno Yasurou, Oda Naruhito, Wada Kiyoko, Miyamoto Masahide, Yokoe Takuya, Hashimoto Tadanori, Minoguchi Hideko, Miyamoto Masahide, Yokoe Takuya, Hashimoto Tadanori, Minoguchi Hideko, Tanaka Akihiko, Kokubu Fumio, Adachi Mitsuru
First Department of Internal Medicine, Showa University.
Arerugi. 2002 Jul;51(7):565-70.
It is well known that allergic rhinitis and asthma often coexist in the same patients. Here, we investigated the influence of Japanese cedar pollinosis on the exacerbation of asthma investigated by questionnaire, daily asthma diary, and peak expiratory flow (PEF) monitoring. Furthermore, airway responsiveness to histamine before pollen season was also investigated in some patients. 333 adult patients with asthma were enrolled into the study and 116 patients (34.8%) were suffering from Japanese cedar pollinosis diagnosed by the presence of nasal allergic symptoms during pollen season and high titer of Japanese cedar-specific IgE antibody. Exacerbation of asthma symptoms, including wheezing, dyspnea, cough, and sputum, was detected in 41 of 116 patients (35.3%) during pollen season. Decrease in morning PEF more than 10% compared with the baseline values before pollen season was observed in 13 of 41 patients (11.2% of total asthmatic patients who complicated with Japanese cedar pollinosis). No significant differences in airway responsiveness to histamine and the titer of Japanese cedar-specific IgE antibodies before pollen season were observed between the patients whose asthma exacerbated and the patients whose asthma was not exacerbated. These results suggest that Japanese cedar pollinosis is one of risk factors for asthma in Japanese adult patients with asthma.
众所周知，变应性鼻炎和哮喘常常在同一患者中并存。在此，我们通过问卷调查、每日哮喘日记和呼气峰值流速（PEF）监测，研究了日本雪松花粉症对哮喘加重的影响。此外，还对部分患者在花粉季节前对组胺的气道反应性进行了研究。333例成年哮喘患者纳入本研究，其中116例患者（34.8%）患有日本雪松花粉症，根据花粉季节出现的鼻部过敏症状以及高滴度的日本雪松特异性IgE抗体确诊。在花粉季节，116例患者中有41例（35.3%）出现哮喘症状加重，包括喘息、呼吸困难、咳嗽和咳痰。41例患者中有13例（占合并日本雪松花粉症的哮喘患者总数的11.2%）观察到早晨PEF较花粉季节前的基线值下降超过10%。哮喘加重患者与未加重患者在花粉季节前对组胺的气道反应性以及日本雪松特异性IgE抗体滴度方面未观察到显著差异。这些结果表明，日本雪松花粉症是日本成年哮喘患者哮喘发作的危险因素之一。
