Kawamoto H, Kambe M, Yamagata M, Kuraoka T
Department of Clinical Laboratory Medicine, Hiroshima University, School of Medicine.
Arerugi. 1999 Oct;48(10):1161-5.
Japanese cedar pollinosis (Type I allergy to Japanese cedar pollen) shows a high incidence in spring in Japan, demonstrating symptoms such as pituita, rhinostenosis, lacrimation and sometimes pharyngeal pain. The following study investigated whether expired nitric oxide (NO) concentration is increased in Japanese cedar pollinosis, and whether expired NO concentration can be used to discriminate from cold syndrome which symptoms are similar to Japanese cedar pollinosis.
In 20 healthy subjects, 20 patients with Japanese cedar pollinosis and 20 patients with cold syndrome, expired NO concentrations derived from nasal cavity and those derived from airway and lung were measured. Expired NO concentrations derived from nasal cavity and those derived from airway and lung were compared among the groups.
In patients with Japanese cedar pollinosis expired NO concentrations derived from nasal cavity and those derived from airway and lung markedly increased. In patients with cold syndrome there were no significant increases in these concentrations.
It is considered that expired NO concentration is useful for discriminating Japanese cedar pollinosis from cold syndrome. It seems interesting that not only expired NO concentrations derived from nasal cavity but also those derived from airway and lung were clevated. Generalized airway inflammation may be present, even without clinical asthma, in patients with Japanese cedar pollinosis.
日本雪松花粉症（对日本雪松花粉的I型过敏）在日本春季发病率很高，表现出诸如流鼻涕、鼻狭窄、流泪等症状，有时还伴有咽痛。以下研究调查了日本雪松花粉症患者呼出一氧化氮（NO）浓度是否升高，以及呼出NO浓度是否可用于与症状类似于日本雪松花粉症的感冒综合征相鉴别。
对20名健康受试者、20名日本雪松花粉症患者和20名感冒综合征患者，测量鼻腔呼出NO浓度以及气道和肺部呼出NO浓度。比较各组鼻腔呼出NO浓度以及气道和肺部呼出NO浓度。
日本雪松花粉症患者鼻腔呼出NO浓度以及气道和肺部呼出NO浓度显著升高。感冒综合征患者这些浓度无显著升高。
认为呼出NO浓度有助于鉴别日本雪松花粉症和感冒综合征。有趣的是，不仅鼻腔呼出NO浓度升高，气道和肺部呼出NO浓度也升高。日本雪松花粉症患者即使没有临床哮喘，也可能存在全身性气道炎症。
