Dai Yuan-Chang, Wu Huei-Min, Chang Chia-Wei, Liou Chiou-Ping, Tzeng Ching-Cherng
Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi (Taipei). 2002 Jun;65(6):293-7.
Malignant spindle cell neoplasms are often a diagnostic challenge in histopathology, especially those arising from unusual locations. The authors report a primary synovial sarcoma of the kidney in a 19-year-old female. Initially, the tumor was considered adult Wilms' tumor exhibiting predominantly blastemal component. It was then revised to monophasic synovial sarcoma due to discovery of the characteristic chromosomal translocation (X;18)(p11.2;q11.2). This is the tenth reported case of renal synovial sarcoma with genetic confirmation. In addition to emphasizing the usefulness of genetic study in diagnostic pathology, the clinical implication of SYT/SSX subtypes and other additional chromosomal changes were also discussed by reviewing literature.
恶性梭形细胞瘤在组织病理学中常常是一个诊断难题，尤其是那些起源于不寻常部位的肿瘤。作者报告了一例19岁女性的原发性肾滑膜肉瘤。最初，该肿瘤被认为是主要表现为胚芽成分的成人威尔姆斯瘤。随后，由于发现了特征性的染色体易位（X；18）（p11.2；q11.2），其被修订为单相滑膜肉瘤。这是第十例经基因确认的肾滑膜肉瘤病例。除了强调基因研究在诊断病理学中的作用外，还通过文献复习讨论了SYT/SSX亚型及其他额外染色体变化的临床意义。
