Silveira Alda M S, Bethony Jeffrey, Gazzinelli Andrea, Kloos Helmut, Fraga Lucia Alves de Oliveira, Alvares Maria Carolina B, Prata Aluizio, Guerra Henrique L, Loverde Philip T, Correa-Oliveira Rodrigo, Gazzinelli Giovanni
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal Minas Gerais, Belo Horizonte, Brazil.
Am J Trop Med Hyg. 2002 May;66(5):542-9. doi: 10.4269/ajtmh.2002.66.542.
Specific IgG4 and IgE responses to adult worm antigen and soluble egg antigen (SEA) were examined in 267 individuals from an area in which schistosomiasis mansoni is endemic. Based on information obtained from clinical and sonographic examinations of this sample, the individuals were divided in three groups: 1) 204 individuals without periportal fibrosis, and liver and spleen enlargements; 2) 41 individuals without periportal fibrosis, but presenting with organopathy, with or without organomegaly; and 3) 22 individuals with periportal fibrosis, regardless of their status as having hepatomegaly and/or splenomegaly. Levels of IgG4 to SEA were significantly higher in sera from patients with fibrosis compared with the patients from the other two groups. We also found significantly higher levels of IgG4 against SEA in egg-negative patients with fibrosis compared with egg-negative patients from the other two groups. This report demonstrates a specific humoral response in patients presenting with initial fibrosis, a form of schistosomiasis transient between intestinal and severe hepatosplenic.
在曼氏血吸虫病流行地区的267名个体中，检测了针对成虫抗原和可溶性虫卵抗原（SEA）的特异性IgG4和IgE反应。根据对该样本进行临床和超声检查所获得的信息，这些个体被分为三组：1）204名无门静脉周围纤维化、肝脏和脾脏肿大的个体；2）41名无门静脉周围纤维化，但有器官病变，有或无器官肿大的个体；3）22名有门静脉周围纤维化的个体，无论其是否有肝肿大和/或脾肿大。与其他两组患者相比，纤维化患者血清中针对SEA的IgG4水平显著更高。我们还发现，与其他两组的虫卵阴性患者相比，纤维化的虫卵阴性患者中针对SEA的IgG4水平也显著更高。本报告证明了在出现初始纤维化的患者中存在特异性体液反应，这是一种介于肠道型和严重肝脾型之间的血吸虫病短暂形式。
