简化的洛巴他胺类似物的合成及V-ATP酶抑制作用
Synthesis and V-ATPase inhibition of simplified lobatamide analogues.
作者信息
Shen Ruichao, Lin Cheng Ting, Bowman Emma Jean, Bowman Barry J, Porco John A
机构信息
Department of Chemistry and Center for Streamlined Synthesis, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Massachusetts 02215, USA.
出版信息
Org Lett. 2002 Sep 5;4(18):3103-6. doi: 10.1021/ol026391z.
PMID:12201727
Abstract
[structure: see text] Simplified analogues of the lobatamides have been synthesized and evaluated for inhibition of bovine V-ATPase. The salicylate phenol, enamide NH, and the ortho-substitution of the salicylate ester have been shown to be important for V-ATPase inhibitory activity.
摘要
[结构：见正文] 已合成了洛巴酰胺的简化类似物，并对其抑制牛V-ATP酶的活性进行了评估。结果表明，水杨酸酚、烯酰胺NH以及水杨酸酯的邻位取代对于V-ATP酶抑制活性很重要。
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