高等动物中的基因转移：理论思考与关键概念
Gene transfer in higher animals: theoretical considerations and key concepts.
作者信息
Smith Kevin R
机构信息
Division of Life Sciences, University of Abertay, Dundee DD1 1HG, UK.
出版信息
J Biotechnol. 2002 Oct 9;99(1):1-22. doi: 10.1016/s0168-1656(02)00105-0.
Abstract
Gene transfer technology provides the ability to genetically manipulate the cells of higher animals. Gene transfer permits both germline and somatic alterations. Such genetic manipulation is the basis for animal transgenesis goals and gene therapy attempts. Improvements in gene transfer are required in terms of transgene design to permit gene targeting, and in terms of transfection approaches to allow improved transgene uptake efficiencies.
摘要
基因转移技术为对高等动物细胞进行基因操作提供了可能。基因转移允许种系和体细胞发生改变。这种基因操作是动物转基因目标和基因治疗尝试的基础。在转基因设计方面需要改进以实现基因靶向，在转染方法方面也需要改进以提高转基因摄取效率。
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