将基因直接导入小鼠睾丸，作为一种转染成熟精子和附睾管内衬上皮细胞的可能方法。
Direct gene delivery to murine testis as a possible means of transfection of mature sperm and epithelial cells lining epididymal ducts.
作者信息
Sato Masahiro
机构信息
Division of Basic Molecular Science and Molecular Medicine, School of Medicine, Tokai University, Kanagawa, Japan.
出版信息
Reprod Med Biol. 2006 Mar 1;5(1):1-7. doi: 10.1111/j.1447-0578.2006.00117.x. eCollection 2006 Mar.
Abstract
The use of a sperm cell to introduce exogenous DNA into an oocyte at the time of fertilization is of interest for the simple production of transgenic mice, and is now called 'sperm-mediated gene transfer (SMGT)'. transfection of sperm cells has been developed as an alternative method for SMGT and can be carried out by direct gene delivery into an interstitial space in a testis (now called 'testis-mediated gene transfer [TMGT]'), into the vas deferens, or into seminiferous tubules. This review summarizes what has been achieved in the field of gene transfer using sperm cells. (Reprod Med Biol 2006; : 1-7).
摘要
在受精时利用精子细胞将外源DNA导入卵母细胞，这对于简单地生产转基因小鼠很有意义，现在被称为“精子介导的基因转移（SMGT）”。精子细胞转染已发展成为SMGT的一种替代方法，可以通过将基因直接导入睾丸的间质空间（现在称为“睾丸介导的基因转移[TMGT]”）、输精管或生精小管来实现。这篇综述总结了在利用精子细胞进行基因转移领域所取得的成果。（《生殖医学与生物学》2006年；：1 - 7）
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