Li Chun
Department of Experimental Diagnostic Imaging, Box 59, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Adv Drug Deliv Rev. 2002 Sep 13;54(5):695-713. doi: 10.1016/s0169-409x(02)00045-5.
Chemotherapy has had limited success in the treatment of cancer over the years, due, in part, to the untoward toxicity of the therapeutic agent to normal cells. The design of tailor-made polymer conjugates provides a synthetic approach that can overcome some of the problems. Several synthetic polymer-based anticancer drug conjugates have entered clinical studies. This report reviews the chemistry, physicochemical properties, and therapeutic applications in cancer therapy of polymeric chemotherapeutic agents based on poly(L-glutamic acid). Targeted delivery of anticancer agents using poly(L-glutamic acid) as the drug carrier is also discussed with emphasis on the design of innovative polymeric constructs.
多年来，化疗在癌症治疗中的成效有限，部分原因在于治疗药物对正常细胞具有不良毒性。量身定制的聚合物缀合物的设计提供了一种能够克服某些问题的合成方法。几种基于合成聚合物的抗癌药物缀合物已进入临床研究阶段。本报告综述了基于聚（L-谷氨酸）的聚合物化疗药物的化学性质、物理化学性质及其在癌症治疗中的应用。还讨论了以聚（L-谷氨酸）作为药物载体进行抗癌药物的靶向递送，重点在于创新聚合物构建体的设计。
