Bui Hoang Linh, Nguyen Hoang Nam, Lai Jui-Yang, Huang Chun-Jen
Faculty of Biotechnology, Chemistry, and Environmental Engineering, PHENIKAA School of Engineering, PHENIKAA University, Hanoi, 12116, Viet Nam.
Faculty of Automation Engineering, Can Tho University, 3/2 Street, Can Tho city, 900000, Viet Nam.
Mater Today Bio. 2025 Jul 12;33:102085. doi: 10.1016/j.mtbio.2025.102085. eCollection 2025 Aug.
Zwitterionic hydrogels have garnered significant attention for their exceptional anti-fouling properties and biocompatibility. These materials have been further enhanced through the incorporation of highly crosslinked 3D networks, endowing them with novel physicochemical characteristics such as stimuli-responsive swelling, ion conductivity, and antibacterial capabilities. In certain cases, zwitterionic motifs can impart self-healing properties for hydrogels, potentially paving the way for the development of functional biomaterials that closely mimic biological tissues. In recent years, we have witnessed substantial efforts from the scientific community to harness the potential of zwitterionic hydrogels for various biomedical applications. This review offers a comprehensive examination of the design principles underlying these materials, spanning from molecular engineering aspects to recent advancements in synthesis routes and fabrication methods. The discussion encompasses the advantages and limitations of different preparation processes, as well as prospects for zwitterionic hydrogels. As a result, this review aims to provide valuable insights for researchers and engineers working to optimize zwitterionic hydrogels for specific biomedical applications, including drug delivery, tissue engineering, and biosensors.
两性离子水凝胶因其出色的抗污性能和生物相容性而备受关注。通过引入高度交联的三维网络，这些材料得到了进一步增强，赋予它们诸如刺激响应性肿胀、离子导电性和抗菌能力等新的物理化学特性。在某些情况下，两性离子基序可以赋予水凝胶自愈性能，这可能为开发紧密模拟生物组织的功能性生物材料铺平道路。近年来，我们目睹了科学界为利用两性离子水凝胶在各种生物医学应用中的潜力所做出的大量努力。本综述全面审视了这些材料的设计原理，涵盖从分子工程方面到合成路线和制备方法的最新进展。讨论包括不同制备工艺的优缺点以及两性离子水凝胶的前景。因此，本综述旨在为致力于优化两性离子水凝胶以用于特定生物医学应用（包括药物递送、组织工程和生物传感器）的研究人员和工程师提供有价值的见解。
