Hanaoka T, Kawamura N, Hara K, Tsugane S
Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Chiba 277-8577, Japan.
Occup Environ Med. 2002 Sep;59(9):625-8. doi: 10.1136/oem.59.9.625.
To evaluate effects of exposure to bisphenol A diglycidyl ether (BADGE) on urinary excretion of bisphenol A, and plasma gonadotrophic hormones and testosterone in male epoxy resin sprayers.
Cross sectional study of 42 workers whose job was to spray epoxy resin hardening agents including BADGE and mixed organic solvents, and 42 matched control workers without BADGE use in the same machine plants.
Concentrations of urinary bisphenol A were higher in the epoxy resin sprayers (median 1.06 micro mol/mol creatinine) compared with the controls (median 0.52 micro mol/mol creatinine). Urinary metabolite concentrations of organic solvents used were all higher in the epoxy resin workers compared with the controls. Endocrinological examination showed different concentrations of follicle stimulating hormone (FSH) between the epoxy sprayers (median 5.3 mIU/ml) and the controls (median 7.6 mIU/ml). FSH showed a mild correlation with urinary bisphenol A, but not with the metabolites of organic solvents. Luteinising hormone and free testosterone concentrations did not differ between the two groups.
BADGE may generate bisphenol A endogenously. Results suggest that bisphenol A may disrupt secretion of gonadotrophic hormones in men. The clinical significance of endocrine disrupting effects by bisphenol A should be further investigated in male workers exposed to bisphenol A.
评估双酚A二缩水甘油醚（BADGE）暴露对男性环氧树脂喷漆工人尿液中双酚A排泄以及血浆促性腺激素和睾酮的影响。
对42名从事喷涂含BADGE的环氧树脂硬化剂及混合有机溶剂工作的工人，以及42名在同一机械厂中未接触BADGE的匹配对照工人进行横断面研究。
环氧树脂喷漆工人尿液中双酚A的浓度（中位数为1.06微摩尔/摩尔肌酐）高于对照组（中位数为0.52微摩尔/摩尔肌酐）。环氧树脂工人使用的有机溶剂的尿液代谢物浓度均高于对照组。内分泌检查显示，环氧树脂喷漆工人（中位数为5.3 mIU/ml）和对照组（中位数为7.6 mIU/ml）之间的促卵泡激素（FSH）浓度不同。FSH与尿液中的双酚A呈轻度相关性，但与有机溶剂的代谢物无关。两组之间的促黄体生成素和游离睾酮浓度没有差异。
BADGE可能会内源性产生双酚A。结果表明，双酚A可能会干扰男性促性腺激素的分泌。双酚A内分泌干扰作用的临床意义应在接触双酚A的男性工人中进一步研究。
