FCS-UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.
CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal.
Int J Mol Sci. 2023 Aug 4;24(15):12417. doi: 10.3390/ijms241512417.
Endocrine disruptor chemicals (EDCs) can have a harmful effect on the human body's endocrine system and thus adversely affect the development, reproduction, neurological, cardiovascular, and immune systems and metabolism in humans and wildlife. According to the World Health Organization, EDCs are mostly man-made and found ubiquitously in our daily lives, notably in pesticides, metals, and additives or contaminants in food and personal care products. Human exposure occurs through ingestion, inhalation, and dermal contact. Bisphenol A (BPA) is a proven EDC capable of mimicking or blocking receptors and altering hormone concentrations and metabolism. Although consumed in low doses, it can stimulate cellular responses and affect the body's functions. In humans, exposure to BPA has been correlated with the onset or development of several diseases. This literature review aimed to verify the effects of BPA on human male infertility using the most recently published literature. Thus, this review allowed us to conclude that this compound seems to have harmful effects on human male fertility, causing changes in hormonal and semen characteristics. However, these conclusions lack more robust and reproducible scientific studies. Even so, and since male infertility prevalence is increasing, preventive measures must be taken to ensure male fertility.
内分泌干扰化学物质 (EDCs) 可能对人体内分泌系统造成有害影响，从而对人类和野生动物的发育、生殖、神经、心血管和免疫系统以及新陈代谢产生不利影响。世界卫生组织表示，EDCs 大多是人为制造的，在日常生活中随处可见，尤其是在农药、金属以及食品和个人护理产品中的添加剂或污染物中。人类通过摄入、吸入和皮肤接触暴露于 EDCs。双酚 A (BPA) 是一种已被证实的 EDC，能够模拟或阻断受体，并改变激素浓度和新陈代谢。尽管摄入量低，但它仍能刺激细胞反应并影响身体的功能。在人类中，接触 BPA 与多种疾病的发生或发展有关。本文献综述旨在使用最新发表的文献验证 BPA 对男性不育的影响。因此，本综述得出结论，这种化合物似乎对人类男性生育能力有不良影响，导致激素和精液特征发生变化。然而，这些结论缺乏更强大和可重复的科学研究。即便如此，由于男性不育症的患病率正在上升，必须采取预防措施来确保男性生育能力。
