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1
Acute effects of carbon monoxide on the metabolism of perfused rat liver.一氧化碳对灌注大鼠肝脏代谢的急性影响。
Biochem J. 1975 Nov;152(2):425-7. doi: 10.1042/bj1520425.
2
The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism.胰岛素和果糖对灌注肝脏代谢的即时影响。脂蛋白分泌、脂肪酸氧化与酯化、脂肪生成及碳水化合物代谢的变化。
Biochem J. 1972 Jan;126(2):295-311. doi: 10.1042/bj1260295.
3
Role of blood flow in carbon monoxide- and hypoxic hypoxia-induced alterations in hexobarbital metabolism in rats.血流在一氧化碳和低氧性缺氧诱导的大鼠己巴比妥代谢改变中的作用
Drug Metab Dispos. 1976 Sep-Oct;4(5):460-7.
4
Direct effect of carbon monoxide on hexobarbital metabolism in the isolated perfused liver in the absence of hemoglobin.在无血红蛋白情况下一氧化碳对离体灌注肝脏中己巴比妥代谢的直接作用。
J Toxicol Environ Health. 1985;15(6):847-54. doi: 10.1080/15287398509530710.
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Influence of ethanol on the metabolism of perfused normal, fatty and cirrhotic rat livers.乙醇对灌注的正常、脂肪性和肝硬化大鼠肝脏代谢的影响。
Biochem J. 1966 Sep;100(3):768-78. doi: 10.1042/bj1000768.
6
The continuous kinetic determination of p-nitroanisole O-demethylation in hemoglobin-free perfused rat liver.在无血红蛋白灌注大鼠肝脏中对4-硝基苯甲醚O-去甲基化进行连续动力学测定。
J Pharmacol Exp Ther. 1977 May;201(2):498-506.
7
Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway.体外暴露于一氧化碳通过p38丝裂原活化蛋白激酶途径预防肝缺血/再灌注损伤。
Hepatology. 2002 Apr;35(4):815-23. doi: 10.1053/jhep.2002.32467.
8
Acute effects of ethanol on the perfused rat liver. Studies on lipid and carbohydrate metabolism, substrate cycling and perfusate amino acids.乙醇对灌注大鼠肝脏的急性影响。脂质和碳水化合物代谢、底物循环及灌注液氨基酸的研究。
Biochem J. 1979 Oct 15;184(1):97-106. doi: 10.1042/bj1840097.
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Cholesterol is required for secretion of very-low-density lipoprotein by rat liver.胆固醇是大鼠肝脏分泌极低密度脂蛋白所必需的。
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10
Increased secretion of triglyceride and cholesterol following inhibition of long-chain fatty acid oxidation in rat liver.大鼠肝脏中长链脂肪酸氧化受抑制后甘油三酯和胆固醇分泌增加。
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引用本文的文献

1
Impaired sensitivity to insulin of rat livers perfused with blood of diminished haematocrit.用血细胞比容降低的血液灌注的大鼠肝脏对胰岛素的敏感性受损。
Biochem J. 1980 Oct 15;192(1):219-22. doi: 10.1042/bj1920219.

本文引用的文献

1
The Relation of the Action of Carbonic Oxide to Oxygen Tension.一氧化碳的作用与氧张力的关系。
J Physiol. 1895 Jul 18;18(3):201-17. doi: 10.1113/jphysiol.1895.sp000562.
2
DETERMINATION OF THE OXYHAEMOGLOBIN DISSOCIATION CURVES FOR MOUSE AND RAT BLOOD.小鼠和大鼠血液氧合血红蛋白解离曲线的测定
J Physiol. 1964 Dec;175(2):161-71. doi: 10.1113/jphysiol.1964.sp007509.
3
ALPHA-GLYCEROPHOSPHATE AS REGULATORY FACTOR IN FATTY ACID ESTERIFICATION.α-甘油磷酸作为脂肪酸酯化的调节因子
Biochim Biophys Acta. 1964 Feb 24;84:18-23. doi: 10.1016/0926-6542(64)90096-4.
4
Factors influencing the rates of long-chain fatty acid oxidation and synthesis in mammalian systems.影响哺乳动物系统中长链脂肪酸氧化和合成速率的因素。
Physiol Rev. 1961 Jan;41:52-129. doi: 10.1152/physrev.1961.41.1.52.
5
Assimilation and dissimilation of fatty acids by the rat liver.大鼠肝脏对脂肪酸的同化与异化作用。
Am J Physiol. 1959 Jun;196(6):1238-41. doi: 10.1152/ajplegacy.1959.196.6.1238.
6
Regulation of fat metabolism of the liver.肝脏脂肪代谢的调节
Nature. 1967 Aug 12;215(5102):716-8. doi: 10.1038/215716a0.
7
Measurement of flow of carbon atoms from glucose and glycogen glucose to glyceride glycerol and glycerol in rat heart and epididymal adipose tissue. Effects of insulin, adrenaline and alloxan-diabetes.大鼠心脏和附睾脂肪组织中碳原子从葡萄糖、糖原葡萄糖流向甘油三酯甘油和甘油的流量测定。胰岛素、肾上腺素和四氧嘧啶糖尿病的影响。
Biochem J. 1967 Aug;104(2):423-34. doi: 10.1042/bj1040423.
8
Gluconeogenesis in the perfused rat liver.灌注大鼠肝脏中的糖异生作用。
Biochem J. 1966 Nov;101(2):284-92. doi: 10.1042/bj1010284.
9
Interrelationships of hyperinsulinism and hypertriglyceridemia in young patients with coronary heart disease.
Circulation. 1968 Dec;38(6):1156-63. doi: 10.1161/01.cir.38.6.1156.
10
Cigarette smoking. Its relationship to coronary heart disease and related risk factors in the Western Collaborative Group Study.吸烟。在西方协作组研究中其与冠心病及相关危险因素的关系。
Circulation. 1968 Dec;38(6):1140-55. doi: 10.1161/01.cir.38.6.1140.

一氧化碳对灌注大鼠肝脏代谢的急性影响。

Acute effects of carbon monoxide on the metabolism of perfused rat liver.

作者信息

Topping D L

出版信息

Biochem J. 1975 Nov;152(2):425-7. doi: 10.1042/bj1520425.

DOI:10.1042/bj1520425
PMID:1220697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172488/
Abstract
  1. Perfusion of livers with whole blood containing carboxyhaemoglobin decreased hepatic O(2) consumption and triglyceride secretion and raised free fatty acid oxidation. 2. Perfusion with [(14)C]carboxyhaemoglobin indicated that there was negligible hepatic uptake of (14)CO. 3. The observations appear to be due to a decrease in O(2) consumption rather than to specific effects of carboxyhaemoglobin.
摘要
  1. 用含有羧基血红蛋白的全血灌注肝脏会降低肝脏的氧气消耗和甘油三酯分泌，并提高游离脂肪酸氧化。2. 用[¹⁴C]羧基血红蛋白灌注表明肝脏对¹⁴CO的摄取可忽略不计。3. 这些观察结果似乎是由于氧气消耗减少，而非羧基血红蛋白的特定作用。