播散性肺癌中的脉络膜转移：发生率及危险因素
Choroidal metastasis in disseminated lung cancer: frequency and risk factors.
作者信息
Kreusel Klaus-Martin, Wiegel Thomas, Stange Marit, Bornfeld Norbert, Hinkelbein Wolfgang, Foerster Michael H
机构信息
Department of Ophthalmology, University Hospital Benjamin Franklin, Free University of Berlin, Germany.
出版信息
Am J Ophthalmol. 2002 Sep;134(3):445-7. doi: 10.1016/s0002-9394(02)01580-5.
PURPOSE
To determine frequency, risk factors, and benefit of a prospective screening for intraocular metastasis in patients with metastatic lung cancer.
DESIGN
Consecutive observational case series.
METHODS
An ophthalmologic screening was performed on 84 consecutive patients suffering from metastatic lung cancer. Medical history and disease stage were evaluated in regard to the risk for intraocular metastasis.
RESULTS
In six patients (7.1%) choroidal metastasis (CM) was detected. Choroidal metastasis was present only when at least two other organ system were affected by metastasis (P =.03). The choroid was the sixth common site of organ metastasis. Mean remaining life span in patients with CM was 1.9 (0.2-5.9) months.
CONCLUSIONS
Choroidal metastasis is common in advanced metastatic lung cancer. However, due to the short survival of affected individuals, a systematic screening of at-risk patients for CM seems to be of limited benefit.
目的
确定对转移性肺癌患者进行眼内转移前瞻性筛查的频率、危险因素及益处。
设计
连续观察性病例系列。
方法
对84例连续的转移性肺癌患者进行眼科筛查。评估病史和疾病分期与眼内转移风险的关系。
结果
在6例患者（7.1%）中检测到脉络膜转移（CM）。仅当至少有两个其他器官系统受转移影响时才会出现脉络膜转移（P = 0.03）。脉络膜是器官转移的第六常见部位。CM患者的平均剩余寿命为1.9（0.2 - 5.9）个月。
结论
脉络膜转移在晚期转移性肺癌中很常见。然而，由于受影响个体的生存期较短，对高危患者进行CM的系统筛查似乎益处有限。
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