Kreusel Klaus-Martin, Bechrakis Nikolaos E, Krause Lothar, Wiegel Thomas, Foerster Michael H
Eye Centre, DRK Clinic Westend, Berlin, Germany.
Acta Ophthalmol Scand. 2007 May;85(3):298-302. doi: 10.1111/j.1600-0420.2006.00828.x.
To determine the clinical incidence and characteristics of symptomatic choroidal metastasis (CM) in breast cancer.
Forty-six consecutive patients with CM from breast cancer were retrospectively reviewed in respect of ocular findings, medical history and systemic disease. Clinical incidence of CM was determined and compared with the incidence predicted from prevalence data obtained in ocular screening studies.
Choroidal metastasis occurred with a median interval of 42.4 months after diagnosis of breast cancer and was predominantly unilateral (63% patients) and solitary (57% affected eyes). A total of 32% of patients had no history of metastatic tumour disease, but systemic screening with CT and scintigraphy revealed metastatic disease in 100% of patients. A median number of three other organs were affected by metastasis. Median survival from diagnosis of CM was 13.1 months. The mean number of local patients diagnosed with CM was 2.9 per year, which was one order of magnitude less than predicted from clinical screening studies.
Choroidal metastasis occurs in advanced metastatic breast cancer, indicating a grave vital prognosis. In a minority of patients (32%) it is the first sign of metastatic disease. The clinical incidence of CM is far smaller than predicted from prevalence data obtained from ocular screening studies.
确定乳腺癌患者中症状性脉络膜转移（CM）的临床发病率及特征。
对46例连续性乳腺癌脉络膜转移患者的眼部检查结果、病史及全身疾病进行回顾性分析。确定CM的临床发病率，并与眼部筛查研究中根据患病率数据预测的发病率进行比较。
脉络膜转移发生于乳腺癌诊断后的中位间隔时间为42.4个月，主要为单侧（63%的患者）和单个病灶（57%的患眼）。共有32%的患者无转移性肿瘤疾病史，但CT和闪烁扫描的全身筛查显示100%的患者存在转移性疾病。其他器官转移受累的中位数量为3个。CM诊断后的中位生存期为13.1个月。每年诊断出CM的本地患者平均数量为2.9例，这比临床筛查研究所预测的少一个数量级。
脉络膜转移发生于晚期转移性乳腺癌，提示预后严重。少数患者（32%）中，它是转移性疾病的首发症状。CM的临床发病率远低于眼部筛查研究中根据患病率数据预测的结果。
