急性早幼粒细胞白血病如何让砷重获新生。
How acute promyelocytic leukaemia revived arsenic.
作者信息
Zhu Jun, Chen Zhu, Lallemand-Breitenbach Valérie, de Thé Hugues
机构信息
CNRS UPR 9051, Laboratoire associé du comité de Paris de la ligue contre le cancer, affilié à l'université de Paris VII, Hôpital St Louis, 1 avenue C. Vellefaux, 75475 Paris cedex 10, France.
出版信息
Nat Rev Cancer. 2002 Sep;2(9):705-13. doi: 10.1038/nrc887.
Despite its many therapeutic qualities, arsenic trioxide has been more commonly remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic trioxide to treat acute promyelocytic leukaemia has radically changed this view, providing new insights into the pathogenesis of this malignancy and raising hopes that arsenicals might be useful in treating other cancers.
尽管三氧化二砷具有诸多治疗特性，但比起作为一种抗癌药物，人们更多地是把它当作《包法利夫人》中提到的毒药。三氧化二砷治疗急性早幼粒细胞白血病的能力彻底改变了这一观点，为这种恶性肿瘤的发病机制提供了新的见解，并燃起了含砷化合物可能对治疗其他癌症有用的希望。
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