Navas-Acién Ana, Pollán Marina, Gustavsson Per, Plato Nils
Cancer and Environmental Epidemiology Area, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
Am J Ind Med. 2002 Sep;42(3):214-27. doi: 10.1002/ajim.10107.
Occupational exposures may be related to the development of brain cancer. The objective was to estimate occupational-specific risk of gliomas and meningiomas among Swedish men and women gainfully employed in 1970 over the period 1971-1989, and the influence of occupational exposure to chemical substances.
A dataset linking cancer diagnoses from the Swedish national cancer register to occupational and demographical data obtained in the 1970 census was used to fit log-linear Poisson models, in order to obtain relative risks adjusted by age, period, geographical area and town size. Exposure to 13 chemicals was assessed using a Swedish job-exposure matrix.
The main findings of this study among men were the increased risk of glioma with occupational exposure to arsenic, mercury, and petroleum products and of meningioma with lead. Women in occupational sectors with a higher socio-economic status showed an increased incidence of both, gliomas and meningiomas.
Occupational exposure to some chemicals appeared to be related with an increased risk of glioma and meningioma in men. Exposures involved in glioma and meningioma development seemed to be different.
职业暴露可能与脑癌的发生有关。目的是估计1970年有收入的瑞典男性和女性在1971 - 1989年期间患胶质瘤和脑膜瘤的职业特定风险，以及职业接触化学物质的影响。
使用一个数据集，将瑞典国家癌症登记处的癌症诊断与1970年人口普查中获得的职业和人口数据相链接，以拟合对数线性泊松模型，从而获得按年龄、时期、地理区域和城镇规模调整后的相对风险。使用瑞典工作暴露矩阵评估对13种化学物质的暴露情况。
本研究在男性中的主要发现是，职业接触砷、汞和石油产品会增加患胶质瘤的风险，接触铅会增加患脑膜瘤的风险。社会经济地位较高职业部门的女性患胶质瘤和脑膜瘤的发病率均有所增加。
职业接触某些化学物质似乎与男性患胶质瘤和脑膜瘤的风险增加有关。胶质瘤和脑膜瘤发展过程中涉及的暴露情况似乎有所不同。
