炎症介质——口腔鳞状细胞癌中潜在的生物标志物来源。
Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma.
机构信息
"Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania.
出版信息
J Immunol Res. 2018 Nov 12;2018:1061780. doi: 10.1155/2018/1061780. eCollection 2018.
Abstract
Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.
摘要
口腔鳞状细胞癌（OSCC）是口腔最常见的肿瘤，与较高的发病率和死亡率相关。它是一种多因素疾病，其发生和发展既涉及遗传因素，也涉及环境因素。其发病机制尚未完全阐明，但炎症起关键作用，大量证据支持慢性炎症与癌变之间的关联。此外，越来越多的研究探讨了炎症的不同介质在 OSCC 的早期检测中的作用。在这篇综述中，我们总结了可能有助于诊断的主要炎症标志物，并对 OSCC 的发病机制进行了探讨。
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