Parker Donna R, Lasater Thomas M, Windsor Richard, Wilkins Jeff, Upegui David I, Heimdal James
Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA.
Nicotine Tob Res. 2002 Aug;4(3):305-9. doi: 10.1080/14622200210142715.
We evaluated a new cotinine test strip to assess smoking status. Urine cotinine was measured using cotinine test strips and also by gas chromatographic techniques (GC) (as the reference criterion). Smoking status was assessed with a self-administered questionnaire. The cotinine test strip identified smokers with a very high level of agreement (97.3% using 100 ng/ml and 97.1% using 250 ng/ml for the cutoff point) and non-smokers with a fair-to-moderate level of agreement (74.5% using 100 ng/ml and 86.4% using 250 ng/ml for the cutoff point). These data suggest that the cotinine test strip appears to provide a reasonably accurate measure of smoking status. Since this was the first study to evaluate the cotinine test strip using the test strip prototype, larger clinical trials are needed to evaluate the validity of the cotinine test strip compared to GC measurements to confirm smoking status.
我们评估了一种用于评估吸烟状况的新型可替宁试纸条。使用可替宁试纸条以及气相色谱技术（GC）（作为参考标准）测量尿中可替宁。通过自行填写问卷来评估吸烟状况。可替宁试纸条识别吸烟者的一致性水平非常高（以100 ng/ml为临界值时为97.3%，以250 ng/ml为临界值时为97.1%），识别非吸烟者的一致性水平为中等（以100 ng/ml为临界值时为74.5%，以250 ng/ml为临界值时为86.4%）。这些数据表明，可替宁试纸条似乎能对吸烟状况提供合理准确的测量。由于这是第一项使用试纸条原型评估可替宁试纸条的研究，因此需要更大规模的临床试验来评估与GC测量相比可替宁试纸条确认吸烟状况的有效性。
